caa a22 4500 469033207 CHVBK 20180323132749.0 cr unu---uuuuu 170328e19921001xx s 000 0 eng 10.1007/BF00223545 doi (NATIONALLICENCE)springer-10.1007/BF00223545 Two subtypes of HLA-B51 differing by substitution at position 171 of the α2 helix [Elektronische Daten] [Go Kawaguchi, William Hildebrand, Masaki Hiraiwa, Sachiko Karaki, Takeshi Nagao, Nobuo Akiyama, Hisanori Uchida, Kouichi Kashiwase, Tatsuya Akaza, Robert Williams, Takeo Juji, Peter Parham, Masafumi Takiguchi] Newly defined antigens of the B5, B35 cross-reacting group have been found in Japanese and North American Indians. Nucleotide sequencing of the alleles encoding the Japanese B5.35 antigen and the variant B5 antigen from the Piman Indians show them to be identical. This new allele, B * 5102, differs from B * 5101 by a single nucleotide substitution that changes residue 171 from histidine to tyrosine. Residue 171, which is part of the α2 helix, is believed to contribute directly to peptide interaction in the A pocket of the binding groove and is either histidine or tyrosine in all HLA-A, B, C heavy chains. Tyrosine 171 is shared by B * 5102, B * 3501, B * 3502, and B * 5301 and must be responsible for the serological cross-reactivities of these molecules not shared with B * 5101. Stimulation of lymphocytes from a B * 5101 positive donor with B * 5102 positive cells failed to generate cytotoxic T cells with specificity for the difference between these molecules. However, one out of five clones of cytotoxic T cells raised against B * 5101 failed to lyse targets expressing B * 5102. Substitution of histidine for tyrosine at residue 171 affected recognition of HLA-B35-restricted human minor histocompatibility antigen-specific T cell clones. Springer-Verlag, 1992 Kawaguchi Go Departments of Tumor Biology and Immunology, Tokyo, Japan aut Hildebrand William Departments of Cell Biology and Microbiology and Immunology, Stanford University, 94305, Stanford, CA, USA aut Hiraiwa Masaki Departments of Tumor Biology and Immunology, Tokyo, Japan aut Karaki Sachiko Departments of Tumor Biology and Immunology, Tokyo, Japan aut Nagao Takeshi Departments of Clinical Transplantation, Institute of Medical Science, Tokyo, Japan aut Akiyama Nobuo Departments of Clinical Transplantation, Institute of Medical Science, Tokyo, Japan aut Uchida Hisanori Departments of Clinical Transplantation, Institute of Medical Science, Tokyo, Japan aut Kashiwase Kouichi Departments of Japanese Red Cross Central Blood Center, Tokyo, Japan aut Akaza Tatsuya Departments of Japanese Red Cross Central Blood Center, Tokyo, Japan aut Williams Robert Histocompatibility Laboratory, Blood Systems, Inc., 6220 E. Oak Street, 85257, Scottsdale, AZ, USA aut Juji Takeo Departments of Blood Transfusion Service, Tokyo University Hospital, University of Tokyo, Tokyo, Japan aut Parham Peter Departments of Cell Biology and Microbiology and Immunology, Stanford University, 94305, Stanford, CA, USA aut Takiguchi Masafumi Departments of Tumor Biology and Immunology, Tokyo, Japan aut Immunogenetics Springer-Verlag 37/1(1992-10-01), 57-63 0093-7711 37:1<57 1992 37 251 https://doi.org/10.1007/BF00223545 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00223545 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kawaguchi Go Departments of Tumor Biology and Immunology, Tokyo, Japan aut NATIONALLICENCE 700 1- Hildebrand William Departments of Cell Biology and Microbiology and Immunology, Stanford University, 94305, Stanford, CA, USA aut NATIONALLICENCE 700 1- Hiraiwa Masaki Departments of Tumor Biology and Immunology, Tokyo, Japan aut NATIONALLICENCE 700 1- Karaki Sachiko Departments of Tumor Biology and Immunology, Tokyo, Japan aut NATIONALLICENCE 700 1- Nagao Takeshi Departments of Clinical Transplantation, Institute of Medical Science, Tokyo, Japan aut NATIONALLICENCE 700 1- Akiyama Nobuo Departments of Clinical Transplantation, Institute of Medical Science, Tokyo, Japan aut NATIONALLICENCE 700 1- Uchida Hisanori Departments of Clinical Transplantation, Institute of Medical Science, Tokyo, Japan aut NATIONALLICENCE 700 1- Kashiwase Kouichi Departments of Japanese Red Cross Central Blood Center, Tokyo, Japan aut NATIONALLICENCE 700 1- Akaza Tatsuya Departments of Japanese Red Cross Central Blood Center, Tokyo, Japan aut NATIONALLICENCE 700 1- Williams Robert Histocompatibility Laboratory, Blood Systems, Inc., 6220 E. Oak Street, 85257, Scottsdale, AZ, USA aut NATIONALLICENCE 700 1- Juji Takeo Departments of Blood Transfusion Service, Tokyo University Hospital, University of Tokyo, Tokyo, Japan aut NATIONALLICENCE 700 1- Parham Peter Departments of Cell Biology and Microbiology and Immunology, Stanford University, 94305, Stanford, CA, USA aut NATIONALLICENCE 700 1- Takiguchi Masafumi Departments of Tumor Biology and Immunology, Tokyo, Japan aut NATIONALLICENCE 773 0- Immunogenetics Springer-Verlag 37/1(1992-10-01), 57-63 0093-7711 37:1<57 1992 37 251 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer