caa a22 4500 469033215 CHVBK 20180323132749.0 cr unu---uuuuu 170328e19920501xx s 000 0 eng 10.1007/BF00209290 doi (NATIONALLICENCE)springer-10.1007/BF00209290 Allelic diversity at the primate major histocompatibility complex DRB6 locus [Elektronische Daten] [Alfredo Corell, Pablo Morales, Pilar Varela, Estela Paz-Artal, J. Martin-Villa, Jorge Martinez-Laso, Antonio Arnaiz-Villena] The HLA-DRB6 gene (also called DRBσ/V1) has been found only in about 26% of human HLA haplotypes, i.e.; DR1, DRw10, and DR2-bearing ones (Corell et al. 1991). In contrast, exon-2 DRB6 sequences have been obtained from all tested primates: nine chimpanzees (Pan troglodytes), three gorillas (Gorilla gorilla) and three orangutans (Pongo pygmaeus); other apes which had already been sequenced (one gorilla and one chimpanzee) also had the DRB6 gene. Thus, all apes tested from three different species, some of them evolutionary separated by at least 14-16 million years, bear the DRB6 gene. In addition, more than one gene copy per haplotype has been found in one chimpanzee; this, together with the apparent loss of this gene in some of the human DR haplotypes, may indicate that the DR genome has undergone evolutionary changes more recently and more actively than class I or III genes. In addition, ten different and presumably allelic DRB6 exon-2 sequences have been obtained, and some of them coming from different species are more similar to each other than the one from the same species; this finding goes in favor of the trans-species theory of major histocompatibility complex polymorphism generation. Also, data are presented supporting that DRB6 may be one of the eldest genes of the DRB family, thus one of the first to diverge from the ancestral DRB gene. Springer-Verlag, 1992 Corell Alfredo Department of Immunology, Hospital "12 de Octubre”, 28041, Madrid, Spain aut Morales Pablo Department of Immunology, Hospital "12 de Octubre”, 28041, Madrid, Spain aut Varela Pilar Department of Immunology, Hospital "12 de Octubre”, 28041, Madrid, Spain aut Paz-Artal Estela Department of Immunology, Hospital "12 de Octubre”, 28041, Madrid, Spain aut Martin-Villa J. Department of Immunology, Hospital "12 de Octubre”, 28041, Madrid, Spain aut Martinez-Laso Jorge Department of Immunology, Hospital "12 de Octubre”, 28041, Madrid, Spain aut Arnaiz-Villena Antonio Department of Immunology, Hospital "12 de Octubre”, 28041, Madrid, Spain aut Immunogenetics Springer-Verlag 36/1(1992-05-01), 33-38 0093-7711 36:1<33 1992 36 251 https://doi.org/10.1007/BF00209290 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00209290 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Corell Alfredo Department of Immunology, Hospital "12 de Octubre”, 28041, Madrid, Spain aut NATIONALLICENCE 700 1- Morales Pablo Department of Immunology, Hospital "12 de Octubre”, 28041, Madrid, Spain aut NATIONALLICENCE 700 1- Varela Pilar Department of Immunology, Hospital "12 de Octubre”, 28041, Madrid, Spain aut NATIONALLICENCE 700 1- Paz-Artal Estela Department of Immunology, Hospital "12 de Octubre”, 28041, Madrid, Spain aut NATIONALLICENCE 700 1- Martin-Villa J. Department of Immunology, Hospital "12 de Octubre”, 28041, Madrid, Spain aut NATIONALLICENCE 700 1- Martinez-Laso Jorge Department of Immunology, Hospital "12 de Octubre”, 28041, Madrid, Spain aut NATIONALLICENCE 700 1- Arnaiz-Villena Antonio Department of Immunology, Hospital "12 de Octubre”, 28041, Madrid, Spain aut NATIONALLICENCE 773 0- Immunogenetics Springer-Verlag 36/1(1992-05-01), 33-38 0093-7711 36:1<33 1992 36 251 Metadata rights reserved Springer special CC-BY-NC licence nationallicence SWISSBIB 469033215 BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer