caa a22 4500 469033304 CHVBK 20180323132749.0 cr unu---uuuuu 170328e19920501xx s 000 0 eng 10.1007/BF00209289 doi (NATIONALLICENCE)springer-10.1007/BF00209289 Genetic control of streptococcus-induced hepatic granulomatous lesions in mice [Elektronische Daten] [Chao-Yuan Chen, S. Cohen, M. Zaleski, B. Albini] Hepatic granulomatous lesions were induced in mice by a single intraperitoneal injection of 3 mg of disrupted Streptococcus pyogenes cell-wall material. Mice carrying the H-2 b or H-2 k haplotypes were highly susceptible to the induction and three weeks after the injection produced numerous granulomas. In contrast, mice of the H-2 d haplotype were resistant and produced only a few hepatic granulomas. Resistance was inherited as a dominant trait and in the backcross generation segregated together with the H-2 d phenotype. Testing of the H-2-recombinant mice indicated that the putative gene(s) determining resistance/susceptibility is located to the right of the S and to the left of the D region. Thes location corresponds to the recently described gene cluster consisting of tumor necrosis factor (TNF) and lymphotoxin genes and several BAT sequences. The known effect of TNF on granuloma formation in mice is consistent with a possible effect of TNF genes, and their variants, on S. pyogenes-inducibility of hepatic granulomas in mice. Springer-Verlag, 1992 Chen Chao-Yuan Department of Microbiology, State University of New York, 14214, Buffalo, NY, USA aut Cohen S. Department of Medicine, Veteran's Administration Medical Center, 14215, Buffalo, NY, USA aut Zaleski M. Department of Microbiology, State University of New York, 14214, Buffalo, NY, USA aut Albini B. Department of Medicine, State University of New York, 14215, Buffalo, NY, USA aut Immunogenetics Springer-Verlag 36/1(1992-05-01), 28-32 0093-7711 36:1<28 1992 36 251 https://doi.org/10.1007/BF00209289 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00209289 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Chen Chao-Yuan Department of Microbiology, State University of New York, 14214, Buffalo, NY, USA aut NATIONALLICENCE 700 1- Cohen S. Department of Medicine, Veteran's Administration Medical Center, 14215, Buffalo, NY, USA aut NATIONALLICENCE 700 1- Zaleski M. Department of Microbiology, State University of New York, 14214, Buffalo, NY, USA aut NATIONALLICENCE 700 1- Albini B. Department of Medicine, State University of New York, 14215, Buffalo, NY, USA aut NATIONALLICENCE 773 0- Immunogenetics Springer-Verlag 36/1(1992-05-01), 28-32 0093-7711 36:1<28 1992 36 251 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer