caa a22 4500 469033436 CHVBK 20180323132749.0 cr unu---uuuuu 170328e19920501xx s 000 0 eng 10.1007/BF00661092 doi (NATIONALLICENCE)springer-10.1007/BF00661092 Comparative mapping of IGHG, IGHM, FES , and FOS in domestic cattle [Elektronische Daten] [Tammy Tobin-Janzen, James Womack] The immunoglobulin genes have not been genetically characterized as thoroughly in cattle as in other mammals, particularly humans and mice. Comparative gene mapping in mammals suggests that the bovine immunoglobulin heavy chain genes,IGHG4 andIGHM might be syntenic with theFOS oncogene. Interestingly, however, when these genes were assigned to bovine syntenic groups utilizing a panel of bovine: hamster hybrid somatic cells,IGH genes were shown to be syntenic with theFES oncogene rather thanFOS. In this studyIGH andFES were assigned toBos taurus chromosome 21 whileFOS was assigned to chromosome 10. In addition, bovine-specific immunoglobulin-like sequences were observed in the hybrid somatic cells, and one, IGHML1, was mapped to bovine syntenic group U16. The probes used for somatic-cell mapping were also used to screen a small number of cattle of several different breeds for restriction fragment length polymorphisms.IGHG4 andIGHM were shown to be highly polymorphisms. whileFOS andFES were not. Springer-Verlag, 1992 Tobin-Janzen Tammy Department of Veterinary Pathobiology, Texas A & M University, 77843, College Station, TX, USA aut Womack James Department of Veterinary Pathobiology, Texas A & M University, 77843, College Station, TX, USA aut Immunogenetics Springer-Verlag 36/3(1992-05-01), 157-165 0093-7711 36:3<157 1992 36 251 https://doi.org/10.1007/BF00661092 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00661092 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tobin-Janzen Tammy Department of Veterinary Pathobiology, Texas A & M University, 77843, College Station, TX, USA aut NATIONALLICENCE 700 1- Womack James Department of Veterinary Pathobiology, Texas A & M University, 77843, College Station, TX, USA aut NATIONALLICENCE 773 0- Immunogenetics Springer-Verlag 36/3(1992-05-01), 157-165 0093-7711 36:3<157 1992 36 251 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer