caa a22 4500 469033509 CHVBK 20180323132750.0 cr unu---uuuuu 170328e19920501xx s 000 0 eng 10.1007/BF00661093 doi (NATIONALLICENCE)springer-10.1007/BF00661093 Reptilian class I major histocompatibility complex genes reveal conserved elements in class I structure [Elektronische Daten] [Dario Grossberger, Peter Parham] The polymerase chain reaction was used to isolate clones with class I major histocompatibility complex sequences from fish (carp), amphibian (axolotl), and two species of reptile (lizard and snake). The lizard and snake clones were used to isolate class I cDNA clones. All the sequence showed the expected evolutionary relatedness. The carp and axolotl clones and one lizard cDNA clone lacked the first systeine in the α3 domain which in other class I heavy chains forms an intradomain disulfide bond. A small number of amino acid residues are conserved in the class I heavy chain sequences from all five classes of vertebrates. In the first two domains they are symmetrically clustered and contribute to intra-and interdomain contacts. None of these invariant residues are at peptide-binding, T-cell receptor-interacting, or CD8-binding positions. Springer-Verlag, 1992 Grossberger Dario Department of Cell Biology and Microbiology and Immunology, Stanford University, 94305-5400, Stanford, CA, USA aut Parham Peter Department of Cell Biology and Microbiology and Immunology, Stanford University, 94305-5400, Stanford, CA, USA aut Immunogenetics Springer-Verlag 36/3(1992-05-01), 166-174 0093-7711 36:3<166 1992 36 251 https://doi.org/10.1007/BF00661093 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00661093 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Grossberger Dario Department of Cell Biology and Microbiology and Immunology, Stanford University, 94305-5400, Stanford, CA, USA aut NATIONALLICENCE 700 1- Parham Peter Department of Cell Biology and Microbiology and Immunology, Stanford University, 94305-5400, Stanford, CA, USA aut NATIONALLICENCE 773 0- Immunogenetics Springer-Verlag 36/3(1992-05-01), 166-174 0093-7711 36:3<166 1992 36 251 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer