caa a22 4500 46903355X CHVBK 20180323132750.0 cr unu---uuuuu 170328e19920701xx s 000 0 eng 10.1007/BF00215050 doi (NATIONALLICENCE)springer-10.1007/BF00215050 Possible role of Ab b gene in mouse resistance to EL4 metastases [Elektronische Daten] [Olga Egorov, Yinong Liu, Igor Egorov] "S” (survivor) mutants were produced in mice for genetic analysis of host resistance to metastatic cancer. S-mutants S-27 and S-31 resist transplantation of lymphoma EL4 of parental C57BL/6J (B6) mice while they accept parental skin grafts. Mutant S-27 also resists formation of spontaneous metastases from intradermally growing EL4 tumor into lymp nodes; mutant S-31 is highly susceptible to EL4 metastases. Another mutant. H-2 bm26 (bm26), resists EL4 and rejects B6 skin grafts. Major histocompatibility complex (MHC) class I and class II gene expression was compared in these mutants and normal B6 mice. All three mutants tested, S-27, S-31, and bm26, expressed a low amount of K b mRNA in organspecific fashion. Mutant bm26 and S-31 expressed a low amount of Ab b mRNA and of Ab antigen on their spleen cells. Some oligonucleotide probes designed to hybridize to the second exon of the clss II MHC gene Ab b did not hybridize with DNA from all three mutants. These findings suggest extensive sequence alternations in the Ab b gene in mutants S-27, S-31, and bm26; they also suggest a major role of MHC in the control of host resistance to spontaneous metastases of the EL4 tumor. Springer-Verlag, 1992 Egorov Olga The Jackson Laboratory, 04609, Bar Harbor, ME, USA aut Liu Yinong The Jackson Laboratory, 04609, Bar Harbor, ME, USA aut Egorov Igor The Jackson Laboratory, 04609, Bar Harbor, ME, USA aut Immunogenetics Springer-Verlag 36/4(1992-07-01), 213-218 0093-7711 36:4<213 1992 36 251 https://doi.org/10.1007/BF00215050 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00215050 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Egorov Olga The Jackson Laboratory, 04609, Bar Harbor, ME, USA aut NATIONALLICENCE 700 1- Liu Yinong The Jackson Laboratory, 04609, Bar Harbor, ME, USA aut NATIONALLICENCE 700 1- Egorov Igor The Jackson Laboratory, 04609, Bar Harbor, ME, USA aut NATIONALLICENCE 773 0- Immunogenetics Springer-Verlag 36/4(1992-07-01), 213-218 0093-7711 36:4<213 1992 36 251 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer