caa a22 4500 469033606 CHVBK 20180323132750.0 cr unu---uuuuu 170328e19920701xx s 000 0 eng 10.1007/BF00215051 doi (NATIONALLICENCE)springer-10.1007/BF00215051 Screening mouse mutations for resistance to cancer metastasis [Elektronische Daten] [Olga Egorov, Yinong Liu, Evelyn Sargent, George Drizlikh, Igor Egorov] To research for host genes for resistance/susceptibility to cancer metastasis, mutation analysis was employed. Ten putative mutants of resistance to lymphoma EL4 and four putative mutants of resistance to sarcoma MCA/77-23 of C57BL/6J (B6) mice were produced. These mutants were designated s (for "survivor”) mutants; they do not reject parental strain B6 skin grafts. S-mutants resist moderate tumor cell doses: TD50 values in them were increased by a factor of 12 to 600. Genetic linkage tests showed that five S-mutants were linked to mouse major histocompatibility complex (H-2) and five other S-mutants were not linked to this locus. A group of H-2-linked S-mutants resisting EL4 and a mutant, S-87/2, resisting MCA/77-23 were tested for resistance to spontaneous matastases of the same two tumors, EL4 and MCA/77-23. Two of the mutants, S-31 (lymphoma-resisting) and S-87/2 (sarcoma-resisting), were shown to carry mutations of mouse gene(s) for resistance to tumor metastases. In both of these mutants resistance to the original tumor transplant coexisted with highly increased susceptibility to meatastasis. These mutants are a new tool to study genes for resistance to cancer metastasis and of mechanism of resistance controlled by each individual gene. Springer-Verlag, 1992 Egorov Olga The Jackson Laboratory, 04609, bar Harbor, ME, USA aut Liu Yinong The Jackson Laboratory, 04609, bar Harbor, ME, USA aut Sargent Evelyn The Jackson Laboratory, 04609, bar Harbor, ME, USA aut Drizlikh George The Weizmann Institute of Science, 76100, Rehovot, Israel aut Egorov Igor The Jackson Laboratory, 04609, bar Harbor, ME, USA aut Immunogenetics Springer-Verlag 36/4(1992-07-01), 219-223 0093-7711 36:4<219 1992 36 251 https://doi.org/10.1007/BF00215051 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00215051 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Egorov Olga The Jackson Laboratory, 04609, bar Harbor, ME, USA aut NATIONALLICENCE 700 1- Liu Yinong The Jackson Laboratory, 04609, bar Harbor, ME, USA aut NATIONALLICENCE 700 1- Sargent Evelyn The Jackson Laboratory, 04609, bar Harbor, ME, USA aut NATIONALLICENCE 700 1- Drizlikh George The Weizmann Institute of Science, 76100, Rehovot, Israel aut NATIONALLICENCE 700 1- Egorov Igor The Jackson Laboratory, 04609, bar Harbor, ME, USA aut NATIONALLICENCE 773 0- Immunogenetics Springer-Verlag 36/4(1992-07-01), 219-223 0093-7711 36:4<219 1992 36 251 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer