caa a22 4500 469033630 CHVBK 20180323132750.0 cr unu---uuuuu 170328e19920701xx s 000 0 eng 10.1007/BF00215053 doi (NATIONALLICENCE)springer-10.1007/BF00215053 Positive and negative selection of Tcrb-V6+ T cells [Elektronische Daten] [Kyuhei Tomonari, Sue Fairchild] Tcrb-V6+ T cells are deleted by an endogenous superantigen probably encoded by a mouse mammary tumor provirus (Mtv), Mtv-7, in association with major histocompatibility complex (MHC) class II molecules. In contrast, Tcrb-V6+CD4+ T cells are positively selected by MHC class II E molecules in Mtv-7 − mice. We have examined the levels of Tcrb-V6+CD4+ and Tcrb-V6+CD8+ T cells from six combinations of backcross mice. In this paper we show that: 1) Tcrb-V6+CD8+ T cells can be positively selected by MHC class I molecules; 2) MHC class II A molecules can also influence the levels of Tcrb-V6+CD4+ T cells; 3) Mtv-7 − NZW mice have a new Mtv, Mtv-44, which co-segregates with a gene encoding the partial deletion ligand for Tcrb-V6+ T cells; 4) the remaining Tcrb-V6+ T cells from mice with partial deletion of these T cells appear not to be anergized in the periphery. Springer-Verlag, 1992 Tomonari Kyuhei Transplantation Biology Section, MRC Clinical Research Centre, Watford Road, Harrow, HA1 3UJ, Middlesex, England aut Fairchild Sue Transplantation Biology Section, MRC Clinical Research Centre, Watford Road, Harrow, HA1 3UJ, Middlesex, England aut Immunogenetics Springer-Verlag 36/4(1992-07-01), 230-237 0093-7711 36:4<230 1992 36 251 https://doi.org/10.1007/BF00215053 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00215053 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tomonari Kyuhei Transplantation Biology Section, MRC Clinical Research Centre, Watford Road, Harrow, HA1 3UJ, Middlesex, England aut NATIONALLICENCE 700 1- Fairchild Sue Transplantation Biology Section, MRC Clinical Research Centre, Watford Road, Harrow, HA1 3UJ, Middlesex, England aut NATIONALLICENCE 773 0- Immunogenetics Springer-Verlag 36/4(1992-07-01), 230-237 0093-7711 36:4<230 1992 36 251 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer