caa a22 4500 469033681 CHVBK 20180323132750.0 cr unu---uuuuu 170328e19920801xx s 000 0 eng 10.1007/BF00215657 doi (NATIONALLICENCE)springer-10.1007/BF00215657 T-cell receptor gamma/delta: comparison of gene configurations and function between humans and chimpanzees [Elektronische Daten] [Els Sturm, Ronald Bontrop, Rea Vreugdenhil, Nel Otting, Reinder Bolhuis] The human and chimpanzee T-cell receptor gamma-delta (TCR γδ) bearing cells represent a minor subset (3-8%) of T lymphocytes. In the periphery, the TCR γδ population has a restricted combinatorial repertoire. The TCRD-V1 and-V2 gene products are expressed in a mutually exclusive fashion, whereas, the TCRD-V2 and the TCRG-V9 encoded proteins show, in general, a coordinated expression. Restriction fragment length polymorphism analysis showed conservation of the restriction sites that identify the TCRG-V9 and TCRD-V2 rearrangements. The human TCRG-V9 locus has two alleles, TCRG-V9A1 and TCRG-V9A2 differing at codon position 31. The chimpanzee TCRG-V9 gene product differs from the products of the human TCRG-V9A1 and TCRG-V9A2 allele by two and three amino acid replacements, respectively. The human and the chimpanzee TCRG-V9-TCRD-V2 lymphocytes show a similar specific proliferative and cytolytic response to human Daudi Burkitt's lymphoma cells. Therefore, the amino acid replacements found in the chimpanzee TCRG-V9 gene product do not change the superantigen specificity across this species barrier. Springer-Verlag, 1992 Sturm Els Department of Immunology, Dr. Daniel den Hoed Cancer Center, Rotterdam, The Netherlands aut Bontrop Ronald ITRI/TNO, Rijswijk, The Netherlands aut Vreugdenhil Rea Department of Immunology, Dr. Daniel den Hoed Cancer Center, Rotterdam, The Netherlands aut Otting Nel ITRI/TNO, Rijswijk, The Netherlands aut Bolhuis Reinder Department of Immunology, Dr. Daniel den Hoed Cancer Center, Rotterdam, The Netherlands aut Immunogenetics Springer-Verlag 36/5(1992-08-01), 294-301 0093-7711 36:5<294 1992 36 251 https://doi.org/10.1007/BF00215657 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00215657 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sturm Els Department of Immunology, Dr. Daniel den Hoed Cancer Center, Rotterdam, The Netherlands aut NATIONALLICENCE 700 1- Bontrop Ronald ITRI/TNO, Rijswijk, The Netherlands aut NATIONALLICENCE 700 1- Vreugdenhil Rea Department of Immunology, Dr. Daniel den Hoed Cancer Center, Rotterdam, The Netherlands aut NATIONALLICENCE 700 1- Otting Nel ITRI/TNO, Rijswijk, The Netherlands aut NATIONALLICENCE 700 1- Bolhuis Reinder Department of Immunology, Dr. Daniel den Hoed Cancer Center, Rotterdam, The Netherlands aut NATIONALLICENCE 773 0- Immunogenetics Springer-Verlag 36/5(1992-08-01), 294-301 0093-7711 36:5<294 1992 36 251 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer