caa a22 4500 469033789 CHVBK 20180323132751.0 cr unu---uuuuu 170328e19920601xx s 000 0 eng 10.1007/BF00215282 doi (NATIONALLICENCE)springer-10.1007/BF00215282 Evolutionary relationships among the primate Mhc-DQA1 and DQA2 alleles [Elektronische Daten] [M. Kenter, N. Otting, J. Anholts, J. Leunissen, M. Jonker, R. Bontrop] The variation of the Mhc-DQA1 and DQA2 loci of ten different primate species (hominoids and Old World monkeys) was studied in order to obtain an insight in the processes that generate polymorphism of major histocompatibility complex (Mhc) class II genes and to establish the evolutionary relationships of their alleles. To that end nucleotide sequences of 36 Mhc class II DQA1 and seven DQA2 second exons were determined and phylogenetic trees that illustrate their evolutionary relationships were constructed. We demonstrate the existence of four primate Mhc-DQA1 allele lineages, two of which probably existed before the separation of the ancestors of the hominoids and Old World monkeys (approximately 22-28 million years ago). Mhc-DQA2 sequences were found only in the hominoid species and showed little diversity. We found no evidence for a major contribution of recombinational events to the generation of allelic diversity of the primate Mhc-DQA1 locus. Instead, our data suggest that the primate Mhc-DQA1 and DQA2 loci are relatively stable entities that mutated primarily as a result of point mutations. Springer-Verlag, 1992 Kenter M. Department of Immunohematology and Blood Bank, University Hospital Leiden, P.O. Box 9600, 2333 AA, Leiden, The Netherlands aut Otting N. Primate Center, ITRI-TNO, Rijswijk, The Netherlands aut Anholts J. Department of Immunohematology and Blood Bank, University Hospital Leiden, P.O. Box 9600, 2333 AA, Leiden, The Netherlands aut Leunissen J. CAOS/CAMM Center, Nijmegen, The Netherlands aut Jonker M. Primate Center, ITRI-TNO, Rijswijk, The Netherlands aut Bontrop R. Primate Center, ITRI-TNO, Rijswijk, The Netherlands aut Immunogenetics Springer-Verlag 36/2(1992-06-01), 71-78 0093-7711 36:2<71 1992 36 251 https://doi.org/10.1007/BF00215282 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00215282 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kenter M. Department of Immunohematology and Blood Bank, University Hospital Leiden, P.O. Box 9600, 2333 AA, Leiden, The Netherlands aut NATIONALLICENCE 700 1- Otting N. Primate Center, ITRI-TNO, Rijswijk, The Netherlands aut NATIONALLICENCE 700 1- Anholts J. Department of Immunohematology and Blood Bank, University Hospital Leiden, P.O. Box 9600, 2333 AA, Leiden, The Netherlands aut NATIONALLICENCE 700 1- Leunissen J. CAOS/CAMM Center, Nijmegen, The Netherlands aut NATIONALLICENCE 700 1- Jonker M. Primate Center, ITRI-TNO, Rijswijk, The Netherlands aut NATIONALLICENCE 700 1- Bontrop R. Primate Center, ITRI-TNO, Rijswijk, The Netherlands aut NATIONALLICENCE 773 0- Immunogenetics Springer-Verlag 36/2(1992-06-01), 71-78 0093-7711 36:2<71 1992 36 251 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer