caa a22 4500 469038586 CHVBK 20180323132803.0 cr unu---uuuuu 170328e19920601xx s 000 0 eng 10.1007/BF00816841 doi (NATIONALLICENCE)springer-10.1007/BF00816841 QSAR of copper(II) complexes with cytotoxic properties [Elektronische Daten] [Roberto Cao, Ariana Garcia, Ernestina Castell] QSAR von Kupfer(II)-Komplexen mit cytotoxischen Eigenschaften Summary: A QSAR based on a multiple regression analysis for 15 copper(II) semi- and thiosemicarbazone complexes with cytotoxic properties is presented. "In vitro” cytotoxicity was selected as the dependent variable and Van der Waals volumes (Vm), octanol- water partition coefficients (logP), specific rate constants of the copper(II) complexes towards superoxide radicals (k s ) and variation in C=N vibration bands (ΔCN) in IR spectra of the complexes with respect to the free ligands were selected as the independent variables. The "stepwise regression” procedure and the "all possible regressions” were practiced in the analysis of the data. The orthogonality analysis proved noncollinearity among the variables. According to the obtained equation the two best copper(II) complexes were submitted to a broad "in vivo” screening study and resulted to be active against La, P-388 and L-1210 leukemias. Springer-Verlag, 1992 QSAR nationallicence Thiosemicarbazones nationallicence Copper(II) complexes nationallicence Cytotoxicity nationallicence Antitumoral activity nationallicence Cao Roberto Laboratory of Bioinorganic Chemistry, Faculty of Chemistry, Havana University, 10400, Havana, Cuba aut Garcia Ariana Laboratory of Bioinorganic Chemistry, Faculty of Chemistry, Havana University, 10400, Havana, Cuba aut Castell Ernestina Faculty of Cybernetic-Mathematics, Havana University, 10400, Havana, Cuba aut Monatshefte für Chemie / Chemical Monthly Springer-Verlag 123/6-7(1992-06-01), 487-491 0026-9247 123:6-7<487 1992 123 706 https://doi.org/10.1007/BF00816841 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00816841 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Cao Roberto Laboratory of Bioinorganic Chemistry, Faculty of Chemistry, Havana University, 10400, Havana, Cuba aut NATIONALLICENCE 700 1- Garcia Ariana Laboratory of Bioinorganic Chemistry, Faculty of Chemistry, Havana University, 10400, Havana, Cuba aut NATIONALLICENCE 700 1- Castell Ernestina Faculty of Cybernetic-Mathematics, Havana University, 10400, Havana, Cuba aut NATIONALLICENCE 773 0- Monatshefte für Chemie / Chemical Monthly Springer-Verlag 123/6-7(1992-06-01), 487-491 0026-9247 123:6-7<487 1992 123 706 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer