caa a22 4500 469043970 CHVBK 20180323132818.0 cr unu---uuuuu 170328e19920101xx s 000 0 eng 10.1007/BF01800353 doi (NATIONALLICENCE)springer-10.1007/BF01800353 Comparison of total cellular DNA, mRNA, and rRNA levels between normals and down syndrome patients [Elektronische Daten] [C. McQuillan, K. Choo] Summary: Two recent studies have suggested that the absolute cellular RNA and/or DNA levels in Down syndrome (DS) may be unusual compared to normals and may be linked to phenotypic expression (Pashet al., 1990; Dahlet al. 1988). We have extended these two studies by directly quantitating and comparing the total cellular mRNA, rRNA, and DNA levels in fibroblasts and lymphocytes derived from normal and DS individuals. The assay methods used, which allowed us to present the various nucleic acids levels in picograms per cell, did not reveal any significant difference between the two groups. SSIEM and Kluwer Academic Publishers, 1992 McQuillan C. The Murdoch Institute for Research into Birth Defects, Royal Children's Hospital, Flemington Road, 3052, Parkville, Victoria, Australia aut Choo K. The Murdoch Institute for Research into Birth Defects, Royal Children's Hospital, Flemington Road, 3052, Parkville, Victoria, Australia aut Journal of Inherited Metabolic Disease Kluwer Academic Publishers 15/1(1992-01-01), 112-120 0141-8955 15:1<112 1992 15 10545 https://doi.org/10.1007/BF01800353 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01800353 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- McQuillan C. The Murdoch Institute for Research into Birth Defects, Royal Children's Hospital, Flemington Road, 3052, Parkville, Victoria, Australia aut NATIONALLICENCE 700 1- Choo K. The Murdoch Institute for Research into Birth Defects, Royal Children's Hospital, Flemington Road, 3052, Parkville, Victoria, Australia aut NATIONALLICENCE 773 0- Journal of Inherited Metabolic Disease Kluwer Academic Publishers 15/1(1992-01-01), 112-120 0141-8955 15:1<112 1992 15 10545 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer