caa a22 4500 469044780 CHVBK 20180323132821.0 cr unu---uuuuu 170328e19920701xx s 000 0 eng 10.1007/BF01799623 doi (NATIONALLICENCE)springer-10.1007/BF01799623 The molecular basis of X-linked immunodeficiency disease [Elektronische Daten] [C. Kinnon, R. Levinsky] Summary: The molecular bases of the X-linked immunodeficiency diseases remain largely undetermined. Two of the genes involved in these diseases have been isolated, namely the genes for X-linked chronic granulomatous disease and properdin deficiency, and substantial progress has now been made in identifying the genes which are defective in the other five diseases, Wiskott-Aldrich syndrome, X-linked severe combined immunodeficiency, X-linked agammaglobulinaemia, X-linked hyper-IgM and X-linked lymphoproliferative syndrome. We review here the nature of the diseases, progress made in identifying and isolating the genes involved and the prospects for improved prenatal detection, carrier status determination and treatment of these life-threatening conditions. SSIEM and Kluwer Academic Publishers, 1992 Kinnon C. Molecular Immunology Unit, Institute of Child Health, University of London, 30 Guilford Street, WC1N 1EH, London, UK aut Levinsky R. Molecular Immunology Unit, Institute of Child Health, University of London, 30 Guilford Street, WC1N 1EH, London, UK aut Journal of Inherited Metabolic Disease Kluwer Academic Publishers 15/4(1992-07-01), 674-682 0141-8955 15:4<674 1992 15 10545 https://doi.org/10.1007/BF01799623 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01799623 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kinnon C. Molecular Immunology Unit, Institute of Child Health, University of London, 30 Guilford Street, WC1N 1EH, London, UK aut NATIONALLICENCE 700 1- Levinsky R. Molecular Immunology Unit, Institute of Child Health, University of London, 30 Guilford Street, WC1N 1EH, London, UK aut NATIONALLICENCE 773 0- Journal of Inherited Metabolic Disease Kluwer Academic Publishers 15/4(1992-07-01), 674-682 0141-8955 15:4<674 1992 15 10545 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer