caa a22 4500 469045078 CHVBK 20180323132822.0 cr unu---uuuuu 170328e19920901xx s 000 0 eng 10.1007/BF01800010 doi (NATIONALLICENCE)springer-10.1007/BF01800010 Allopurinol challenge test in children [Elektronische Daten] [A. Burlina, V. Ferrari, C. Dionisi-Vici, A. Bordugo, F. Zacchello, M. Tuchman] Summary: The allopurinol challenge test was performed on 44 healthy subjects (28 children and 16 adolescents) in order to establish normal values of urinary orotic acid excretion following allopurinol ingestion in the paediatric population. The subjects were divided into three groups according to their age: 6 months to 6 years; 6 years to 10 years; and 10 years to 17 years. They were given 100 mg, 200 mg, or 300 mg of allopurinol, respectively (based on age) in a single oral dose. Maximum peak urinary orotic acid levels following ingestion of allopurinol were 13.0 (n=14), 9.3 (n=14), and 10.2 (n=16) µmol/mmol creatinine in the three groups, respectively. In all children tested the peak orotic acid level was 3.1±2.7 µmol/mmol creatinine (mean ± SD,n=44). This allopurinol challenge test was also performed in six children with ureacycle disorders, including five females with ornithine transcarbamylase (OTC) deficiency, all of whom demonstrated abnormally elevated levels of urinary orotic acid (peak levels of 26-134 µmol/mmol creatinine) following allopurinol ingestion. SSIEM and Kluwer Academic Publishers, 1992 Burlina A. Department of Pediatrics, University of Padua, Padua, Italy aut Ferrari V. Department of Pediatrics, University of Padua, Padua, Italy aut Dionisi-Vici C. Department of Metabolism, Bambino Gesu Children's Hospital, Rome, Italy aut Bordugo A. Department of Pediatrics, University of Padua, Padua, Italy aut Zacchello F. Department of Pediatrics, University of Padua, Padua, Italy aut Tuchman M. Division of Genetics and Metaboilsm, Departments of Pediatrics and Laboratory Medicine and Pathology, University of Minnesota, Mayo Memorial Building, 420 Delaware Street, SE, Box 400, 55455, Minneapolis, MN, USA aut Journal of Inherited Metabolic Disease Kluwer Academic Publishers 15/5(1992-09-01), 707-712 0141-8955 15:5<707 1992 15 10545 https://doi.org/10.1007/BF01800010 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01800010 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Burlina A. Department of Pediatrics, University of Padua, Padua, Italy aut NATIONALLICENCE 700 1- Ferrari V. Department of Pediatrics, University of Padua, Padua, Italy aut NATIONALLICENCE 700 1- Dionisi-Vici C. Department of Metabolism, Bambino Gesu Children's Hospital, Rome, Italy aut NATIONALLICENCE 700 1- Bordugo A. Department of Pediatrics, University of Padua, Padua, Italy aut NATIONALLICENCE 700 1- Zacchello F. Department of Pediatrics, University of Padua, Padua, Italy aut NATIONALLICENCE 700 1- Tuchman M. Division of Genetics and Metaboilsm, Departments of Pediatrics and Laboratory Medicine and Pathology, University of Minnesota, Mayo Memorial Building, 420 Delaware Street, SE, Box 400, 55455, Minneapolis, MN, USA aut NATIONALLICENCE 773 0- Journal of Inherited Metabolic Disease Kluwer Academic Publishers 15/5(1992-09-01), 707-712 0141-8955 15:5<707 1992 15 10545 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer