caa a22 4500 469048921 CHVBK 20180323132824.0 cr unu---uuuuu 170328e19920101xx s 000 0 eng 10.1007/BF00164751 doi (NATIONALLICENCE)springer-10.1007/BF00164751 Hanly Patrick Division of Respiratory Medicine, University of Toronto, 247 JB, Wellesley Hospital, 160 Wellesley Street East, M4Y 1J3, Toronto, Ontario, Canada aut Mechanisms and management of central sleep apnea [Elektronische Daten] [Patrick Hanly] Central sleep apnea is not a single disease but represents the final pathway in a large group of heterogeneous disorders. Control of normal breathing during sleep relies upon finely coordinated anatomical and physiological mechanisms and their destabilization leads to central apnea. The causes of central sleep apnea can be classified into 4 groups: neurologic disorders, periodic breathing, upper airway abnormalities, and idiopathic syndromes. Clinical features result from the interaction between the underlying disorder and control of respiration. Two different prototypes emerge: patients who are hypercapnic (central hypoventilation and/or impaired respiratory mechanics) and those who are eucapnic or hypocapnic (periodic breathing and idiopathic hyperventilation). The causes and severity of apnea can be determined by clinical assessment, pulmonary function testing, and overnight polysomnography. Further management involves specific treatment of the underlying condition and reducing the sequelae of recurrent apneas during sleep, namely cardiorespiratory dysfunction and sleep disruption. This review outlines an approach to the management of central sleep apnea based upon an understanding of its pathophysiology. Springer-Verlag, 1992 Sleep apnea nationallicence Periodic breathing nationallicence Upper airway nationallicence Continuous positive airway pressure nationallicence Lung Springer-Verlag 170/1(1992-01-01), 1-17 0341-2040 170:1<1 1992 170 408 https://doi.org/10.1007/BF00164751 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00164751 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Hanly Patrick Division of Respiratory Medicine, University of Toronto, 247 JB, Wellesley Hospital, 160 Wellesley Street East, M4Y 1J3, Toronto, Ontario, Canada aut NATIONALLICENCE 773 0- Lung Springer-Verlag 170/1(1992-01-01), 1-17 0341-2040 170:1<1 1992 170 408 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer