caa a22 4500 469048948 CHVBK 20180323132824.0 cr unu---uuuuu 170328e19920101xx s 000 0 eng 10.1007/BF00164752 doi (NATIONALLICENCE)springer-10.1007/BF00164752 Superoxide dismutase inhibits radiation-induced lung injury in hamsters [Elektronische Daten] [Raphael Breuer, Zelig Tochner, Michael Conner, Abraham Nimrod, Marian Gorecki, Reuven Or, Shimon Slavin] An animal model of pulmonary radiation-induced lung injury was established in the hamster and the effects of pretreatment with recombinant human CuZn superoxide dismutase (SOD) on the development of the lesion were evaluated. Hamsters exposed to a single irradiation dose of 2000 cGy delivered to the thorax were treated with 150 mg/kg body weight of SOD or an equivalent volume of saline intraperitoneally 75 min and subcutaneously 5 min before receiving irradiation. At 4, 8, and 16 weeks following irradiation, pulmonary injury was evaluated by the grading of morphologic changes semiquantitatively, measurement of lung hydroxyproline content, and analysis of bronchoalveolar lavage fluid for total and differential cell counts and total protein concentration. Radiation-induced lung injury in saline-pretreated animals was documented at 16 weeks by histologic morphology and increased protein in bronchoalveolar lavage fluid. SOD protected against radiation-induced pulmonary injury as indicated by the absence of severe histopathologic changes and prevention of elevation in bronchoalveolar lavage protein levels. The beneficial effects of SOD in preventing radiation-induced pulmonary toxicity suggests that this recombinant enzyme may play a role in protection against radiation-induced pulmonary injury in humans. Springer-Verlag, 1992 Superoxide dismutase nationallicence Irradiation nationallicence Radiation pneumonitis nationallicence Lung, injury nationallicence Breuer Raphael Pulmonary Research Laboratory, Radiation Therapy Unit, and Bone Marrow Transplantation Department, Hadassah University Hospital, P.O. Box 12000, 91120, Jerusalem, Israel aut Tochner Zelig Pulmonary Research Laboratory, Radiation Therapy Unit, and Bone Marrow Transplantation Department, Hadassah University Hospital, P.O. Box 12000, 91120, Jerusalem, Israel aut Conner Michael Pulmonary Research Laboratory, Radiation Therapy Unit, and Bone Marrow Transplantation Department, Hadassah University Hospital, P.O. Box 12000, 91120, Jerusalem, Israel aut Nimrod Abraham Pulmonary Research Laboratory, Radiation Therapy Unit, and Bone Marrow Transplantation Department, Hadassah University Hospital, P.O. Box 12000, 91120, Jerusalem, Israel aut Gorecki Marian Pulmonary Research Laboratory, Radiation Therapy Unit, and Bone Marrow Transplantation Department, Hadassah University Hospital, P.O. Box 12000, 91120, Jerusalem, Israel aut Or Reuven Pulmonary Research Laboratory, Radiation Therapy Unit, and Bone Marrow Transplantation Department, Hadassah University Hospital, P.O. Box 12000, 91120, Jerusalem, Israel aut Slavin Shimon Pulmonary Research Laboratory, Radiation Therapy Unit, and Bone Marrow Transplantation Department, Hadassah University Hospital, P.O. Box 12000, 91120, Jerusalem, Israel aut Lung Springer-Verlag 170/1(1992-01-01), 19-29 0341-2040 170:1<19 1992 170 408 https://doi.org/10.1007/BF00164752 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00164752 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Breuer Raphael Pulmonary Research Laboratory, Radiation Therapy Unit, and Bone Marrow Transplantation Department, Hadassah University Hospital, P.O. Box 12000, 91120, Jerusalem, Israel aut NATIONALLICENCE 700 1- Tochner Zelig Pulmonary Research Laboratory, Radiation Therapy Unit, and Bone Marrow Transplantation Department, Hadassah University Hospital, P.O. Box 12000, 91120, Jerusalem, Israel aut NATIONALLICENCE 700 1- Conner Michael Pulmonary Research Laboratory, Radiation Therapy Unit, and Bone Marrow Transplantation Department, Hadassah University Hospital, P.O. Box 12000, 91120, Jerusalem, Israel aut NATIONALLICENCE 700 1- Nimrod Abraham Pulmonary Research Laboratory, Radiation Therapy Unit, and Bone Marrow Transplantation Department, Hadassah University Hospital, P.O. Box 12000, 91120, Jerusalem, Israel aut NATIONALLICENCE 700 1- Gorecki Marian Pulmonary Research Laboratory, Radiation Therapy Unit, and Bone Marrow Transplantation Department, Hadassah University Hospital, P.O. Box 12000, 91120, Jerusalem, Israel aut NATIONALLICENCE 700 1- Or Reuven Pulmonary Research Laboratory, Radiation Therapy Unit, and Bone Marrow Transplantation Department, Hadassah University Hospital, P.O. Box 12000, 91120, Jerusalem, Israel aut NATIONALLICENCE 700 1- Slavin Shimon Pulmonary Research Laboratory, Radiation Therapy Unit, and Bone Marrow Transplantation Department, Hadassah University Hospital, P.O. Box 12000, 91120, Jerusalem, Israel aut NATIONALLICENCE 773 0- Lung Springer-Verlag 170/1(1992-01-01), 19-29 0341-2040 170:1<19 1992 170 408 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer