caa a22 4500 469048972 CHVBK 20180323132824.0 cr unu---uuuuu 170328e19920101xx s 000 0 eng 10.1007/BF00164753 doi (NATIONALLICENCE)springer-10.1007/BF00164753 PAF receptor blockade inhibits lung vascular changes in the rat monocrotaline model [Elektronische Daten] [S. Ono, N. Voelkel] We recently reported that platelet-activating factor (PAF) levels increased in lung tissue after 1 subcutaneous injection of monocrotaline (MCT) (which causes lung injury), and, further, that treatment with PAF antagonists reduced pulmonary hypertension in this chronic lung injury rat model [15]. In the present study, we examined the effect of WEB 2170, a specific PAF antagonist, on MCT-induced pulmonary vascular remodeling. At 3 weeks after MCT injection, pulmonary hypertension in the animals was associated with an increase in the vessel wall thickness of the muscular arteries, reduction in number of peripheral arterioles, and right ventricular hypertrophy. In WEB 2170-treated rats, these changes were significantly less severe when compared with those observed in MCT-treated rats. In MCT-treated rats, there were significant increases in in vitro [3H]thymidine incorporation and accumulation of hydroxyproline in the lung tissue, and these changes were inhibited by WEB 2170 treatment. Our results suggest that PAF or a PAF-dependent sequence of events is involved in MCT-induced lung vascular remodeling. Springer-Verlag, 1992 Platelet-activating factor (PAF) nationallicence Platelet-activating factor antagonist nationallicence Pulmonary vascular remodeling nationallicence Monocrotaline lung disease nationallicence Ono S. Cardiovascular Pulmonary Research Laboratory, University of Colorado Health Sciences Center, 80262, Denver, CO, USA aut Voelkel N. Cardiovascular Pulmonary Research Laboratory, University of Colorado Health Sciences Center, 80262, Denver, CO, USA aut Lung Springer-Verlag 170/1(1992-01-01), 31-40 0341-2040 170:1<31 1992 170 408 https://doi.org/10.1007/BF00164753 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00164753 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ono S. Cardiovascular Pulmonary Research Laboratory, University of Colorado Health Sciences Center, 80262, Denver, CO, USA aut NATIONALLICENCE 700 1- Voelkel N. Cardiovascular Pulmonary Research Laboratory, University of Colorado Health Sciences Center, 80262, Denver, CO, USA aut NATIONALLICENCE 773 0- Lung Springer-Verlag 170/1(1992-01-01), 31-40 0341-2040 170:1<31 1992 170 408 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer