caa a22 4500 469048980 CHVBK 20180323132824.0 cr unu---uuuuu 170328e19921101xx s 000 0 eng 10.1007/BF00177581 doi (NATIONALLICENCE)springer-10.1007/BF00177581 Systemic administration of platelet-activating factor in rat reduces specific pulmonary uptake of circulating monoclonal antibody to angiotensin-converting enzyme [Elektronische Daten] [Elena Atochina, Holger Hiemisch, Vladimir Muzykantov, Sergei Danilov] The biodistribution of radiolabeled mouse monoclonal antibody (MoAb) to angiotensin-converting enzyme (ACE) and control, nonimmune mouse IgG in platelet activating factor (PAF)-treated rats was studied. The blood level of both preparations was slightly decreased (90% of the control) in PAF-treated rats. Specific pulmonary accumulation of anti-ACE MoAb was reduced to 50% of control in contrast to a doubling in nonspecific pulmonary uptake of non-immune IgG. The changes in anti-ACE MoAb biodistribution were lung-specific and were accompanied by decrease in the pulmonary ACE activity (to 60% of control) and increase in serum ACE activity (to 170% of control). Thus anti-ACE MoAb reveals PAF-induced changes in the status of the pulmonary ACE and therefore can be used for the studies of pathology of the pulmonary endothelium. Springer-Verlag New York Inc, 1992 Monoclonal antibody nationallicence Endothelium nationallicence Angiotensin-converting enzyme nationallicence Platelet-activating factor nationallicence Atochina Elena Institute of Experimental Cardiology, 3rd Cherepkovskaja Street, 15a, 121552, Moscow, Russia aut Hiemisch Holger Institute of Experimental Cardiology, 3rd Cherepkovskaja Street, 15a, 121552, Moscow, Russia aut Muzykantov Vladimir Institute of Experimental Cardiology, 3rd Cherepkovskaja Street, 15a, 121552, Moscow, Russia aut Danilov Sergei Institute of Experimental Cardiology, 3rd Cherepkovskaja Street, 15a, 121552, Moscow, Russia aut Lung Springer-Verlag 170/6(1992-11-01), 349-358 0341-2040 170:6<349 1992 170 408 https://doi.org/10.1007/BF00177581 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00177581 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Atochina Elena Institute of Experimental Cardiology, 3rd Cherepkovskaja Street, 15a, 121552, Moscow, Russia aut NATIONALLICENCE 700 1- Hiemisch Holger Institute of Experimental Cardiology, 3rd Cherepkovskaja Street, 15a, 121552, Moscow, Russia aut NATIONALLICENCE 700 1- Muzykantov Vladimir Institute of Experimental Cardiology, 3rd Cherepkovskaja Street, 15a, 121552, Moscow, Russia aut NATIONALLICENCE 700 1- Danilov Sergei Institute of Experimental Cardiology, 3rd Cherepkovskaja Street, 15a, 121552, Moscow, Russia aut NATIONALLICENCE 773 0- Lung Springer-Verlag 170/6(1992-11-01), 349-358 0341-2040 170:6<349 1992 170 408 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer