caa a22 4500 469049014 CHVBK 20180323132825.0 cr unu---uuuuu 170328e19921101xx s 000 0 eng 10.1007/BF00177577 doi (NATIONALLICENCE)springer-10.1007/BF00177577 Combined effects of ozone and cigarette smoke on airway responsiveness and vascular permeability in guinea pigs [Elektronische Daten] [M. Nishikawa, H. Ikeda, H. Nishiyama, H. Yamakawa, S. Suzuki, T. Okubo] The effects of combined exposure to ozone and cigarette smoke on airway responsiveness and tracheal vascular permeability, compared with those of single exposure were examined in guinea pigs. Airway responsiveness was assessed by measuring the specific airway resistance (sRaw) as a function of increasing concentration of inhaled methacholine aerosol immediately, 5 hr, and 24 hr after exposure. In a parallel study, tracheal vascular permeability was quantified by measuring the tracheal extravasation of intravenously administered Evans blue dye. Neither exposure to 1 ppm ozone for 30 min nor 5 puffs of cigarette smoke increased airway responsiveness or vascular permeability at any time after exposure. Combined exposure to 1 ppm ozone for 30 min and 5 puffs of cigarette smoke caused airway hyperresponsiveness and increased vascular permeability immediately after exposure. Exposure to 1 ppm ozone for 90 min increased both airway responsiveness and vascular permeability immediately after exposure. Exposure to 10 puffs of cigarette smoke increased airway responsiveness but not vascular permeability immediately after exposure. Combined exposure to 1 ppm ozone for 90 min and 10 puffs of cigarette smoke increased both airway responsiveness and vascular permeability immediately after exposure. The combined exposure to ozone and cigarette smoke thus increased both airway responsiveness and tracheal vascular permeability to a greater extent than did exposure to a single agent, suggesting that a combination of air pollutants has a more deleterious effect both on airway responsiveness and on tracheal vascular permeability than does either agent alone in guinea pigs. Springer-Verlag New York Inc, 1992 Guinea pig nationallicence Ozone nationallicence Cigarette smoke nationallicence Airway hyper-responsiveness nationallicence Vascular permeability nationallicence Nishikawa M. The First Department of Internal Medicine, Yokohama City University, School of Medicine, 3-9 Fukuura, 236, Kanazawa-ku, Yokohama, Japan aut Ikeda H. The First Department of Internal Medicine, Yokohama City University, School of Medicine, 3-9 Fukuura, 236, Kanazawa-ku, Yokohama, Japan aut Nishiyama H. The First Department of Internal Medicine, Yokohama City University, School of Medicine, 3-9 Fukuura, 236, Kanazawa-ku, Yokohama, Japan aut Yamakawa H. The First Department of Internal Medicine, Yokohama City University, School of Medicine, 3-9 Fukuura, 236, Kanazawa-ku, Yokohama, Japan aut Suzuki S. The First Department of Internal Medicine, Yokohama City University, School of Medicine, 3-9 Fukuura, 236, Kanazawa-ku, Yokohama, Japan aut Okubo T. The First Department of Internal Medicine, Yokohama City University, School of Medicine, 3-9 Fukuura, 236, Kanazawa-ku, Yokohama, Japan aut Lung Springer-Verlag 170/6(1992-11-01), 311-322 0341-2040 170:6<311 1992 170 408 https://doi.org/10.1007/BF00177577 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00177577 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Nishikawa M. The First Department of Internal Medicine, Yokohama City University, School of Medicine, 3-9 Fukuura, 236, Kanazawa-ku, Yokohama, Japan aut NATIONALLICENCE 700 1- Ikeda H. The First Department of Internal Medicine, Yokohama City University, School of Medicine, 3-9 Fukuura, 236, Kanazawa-ku, Yokohama, Japan aut NATIONALLICENCE 700 1- Nishiyama H. The First Department of Internal Medicine, Yokohama City University, School of Medicine, 3-9 Fukuura, 236, Kanazawa-ku, Yokohama, Japan aut NATIONALLICENCE 700 1- Yamakawa H. The First Department of Internal Medicine, Yokohama City University, School of Medicine, 3-9 Fukuura, 236, Kanazawa-ku, Yokohama, Japan aut NATIONALLICENCE 700 1- Suzuki S. The First Department of Internal Medicine, Yokohama City University, School of Medicine, 3-9 Fukuura, 236, Kanazawa-ku, Yokohama, Japan aut NATIONALLICENCE 700 1- Okubo T. The First Department of Internal Medicine, Yokohama City University, School of Medicine, 3-9 Fukuura, 236, Kanazawa-ku, Yokohama, Japan aut NATIONALLICENCE 773 0- Lung Springer-Verlag 170/6(1992-11-01), 311-322 0341-2040 170:6<311 1992 170 408 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer