caa a22 4500 469049022 CHVBK 20180323132825.0 cr unu---uuuuu 170328e19921101xx s 000 0 eng 10.1007/BF00177579 doi (NATIONALLICENCE)springer-10.1007/BF00177579 Cellular sequence of tracheal repair in sheep after smoke inhalation injury [Elektronische Daten] [Robert Barrow, Cheng-Zhong Wang, Robert Cox, Michael Evans] The cellular repair process of injured tracheal epithelium is described for sheep after exposure to toxic smoke containing high concentrations of acrolein. Fourteen fasted 3-4-year-old ewes had a portion of their cervical trachea exposed to cotton smoke for 20 min and then were sacrificed at various time intervals ranging from 1 to 22 days after exposure. Within 1 day of injury, columnar epithelium sloughed intact from the trachea with a concomitant reduction of nearly 35% in the basal cell population. At 2 days of recovery, the cellularity of the epithelium had increased and mitotic figures were observed in some tracheal epithelial and gland cells. By 8 days, undifferentiated hyperplastic cells increased to 30/100 µm, differentiated nonciliated columnar cells first appeared, and the basal cell population returned to a normal count of 13 cells/100µm. Thirteen days after exposure, the undifferentiated hyperplastic cell population had declined to 7 cells/100/ µm, nonciliated columnar cells were at control values, and some ciliated cells were identified. At 18 and 22 days, epithelium was normal in appearance and the count was 13 cells/100µm. Data suggest that because the columnar epithelium sloughs intact with the cilia remaining active, toxic smoke may affect their attachment to the basal lamina. Furthermore, the regeneration process involves differentiation of hyperplastic cells in which they elongate down to the basal lamina, thus re-establishing the integrity of tall, epithelium in the sheep trachea. Springer-Verlag New York Inc, 1992 Tracheal epithelium nationallicence Cell regeneration nationallicence Basal cells nationallicence Ciliated cells nationallicence Toxic smoke injury nationallicence Barrow Robert Departments of Surgery, Physiology and Biophysics, Internal Medicine, and Anatomy and Neurosciences, University of Texas Medical Branch, and Shriners Burns Institute, 815 Market Street, 77550, Galveston, Texas, USA aut Wang Cheng-Zhong Departments of Surgery, Physiology and Biophysics, Internal Medicine, and Anatomy and Neurosciences, University of Texas Medical Branch, and Shriners Burns Institute, 815 Market Street, 77550, Galveston, Texas, USA aut Cox Robert Departments of Surgery, Physiology and Biophysics, Internal Medicine, and Anatomy and Neurosciences, University of Texas Medical Branch, and Shriners Burns Institute, 815 Market Street, 77550, Galveston, Texas, USA aut Evans Michael Departments of Surgery, Physiology and Biophysics, Internal Medicine, and Anatomy and Neurosciences, University of Texas Medical Branch, and Shriners Burns Institute, 815 Market Street, 77550, Galveston, Texas, USA aut Lung Springer-Verlag 170/6(1992-11-01), 331-338 0341-2040 170:6<331 1992 170 408 https://doi.org/10.1007/BF00177579 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00177579 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Barrow Robert Departments of Surgery, Physiology and Biophysics, Internal Medicine, and Anatomy and Neurosciences, University of Texas Medical Branch, and Shriners Burns Institute, 815 Market Street, 77550, Galveston, Texas, USA aut NATIONALLICENCE 700 1- Wang Cheng-Zhong Departments of Surgery, Physiology and Biophysics, Internal Medicine, and Anatomy and Neurosciences, University of Texas Medical Branch, and Shriners Burns Institute, 815 Market Street, 77550, Galveston, Texas, USA aut NATIONALLICENCE 700 1- Cox Robert Departments of Surgery, Physiology and Biophysics, Internal Medicine, and Anatomy and Neurosciences, University of Texas Medical Branch, and Shriners Burns Institute, 815 Market Street, 77550, Galveston, Texas, USA aut NATIONALLICENCE 700 1- Evans Michael Departments of Surgery, Physiology and Biophysics, Internal Medicine, and Anatomy and Neurosciences, University of Texas Medical Branch, and Shriners Burns Institute, 815 Market Street, 77550, Galveston, Texas, USA aut NATIONALLICENCE 773 0- Lung Springer-Verlag 170/6(1992-11-01), 331-338 0341-2040 170:6<331 1992 170 408 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer