caa a22 4500 469049065 CHVBK 20180323132825.0 cr unu---uuuuu 170328e19920501xx s 000 0 eng 10.1007/BF00174318 doi (NATIONALLICENCE)springer-10.1007/BF00174318 Neopterin in tuberculous and neoplastic pleural fluids [Elektronische Daten] [M. Baganha, A. Mota-Pinto, M. Pêgo, M. Marques, M. Santos Rosa, A. Robalo Cordeiro] Neopterin is derived from guanosine-triphosphate, produced by stimulated macrophages under the influence of gamma interferon of lymphocyte origin. It has been suggested as an excellent marker for activation of the monocyte/macrophage axis in some clinical situations. We evaluated its concentration in the pleural effusions of 25 individuals (10 tuberculous and 15 neoplastic) as well as in the blood of 22 of them (8 tuberculous and 14 neoplastic), comparing these levels with those of a control group in 99 normal individuals. The concentration of neopterin was determined by radioimmunologic assay. This showed a significant increase (p < 0.001) of neopterin levels in the tuberculous pleural fluid, compared to the neoplastic group (42 ± 23/17 ± nmol/L). In the blood, values were nearly identical to the pleural fluid (41.3 ±25/15.8 ± 6.9 nmol/L), although with significant differences between them and in relation to the control group (p < 0.001), which had a normal serum value (5.11 ± 1.92 nmol/L). We emphasize the influence of the neopterin levels in the pleural fluid on the diagnosis of causes of pleurisy and its importance as a marker of immunologic cellular activity. Springer-Verlag, 1992 Neopterin nationallicence Tuberculous pleurisy nationallicence Neoplastic pleurisy nationallicence Pleural fluid nationallicence Cellular immunologic marker nationallicence Baganha M. Pneumology Service, University Hospital of Coimbra, 3000, Coimbra, Portugal aut Mota-Pinto A. Immunology Laboratory, College of Medicine, University of Coimbra, 3000, Coimbra, Portugal aut Pêgo M. Pneumology Service, University Hospital of Coimbra, 3000, Coimbra, Portugal aut Marques M. Pneumology Service, University Hospital of Coimbra, 3000, Coimbra, Portugal aut Santos Rosa M. Immunology Laboratory, College of Medicine, University of Coimbra, 3000, Coimbra, Portugal aut Robalo Cordeiro A. Pneumology Service, University Hospital of Coimbra, 3000, Coimbra, Portugal aut Lung Springer-Verlag 170/3(1992-05-01), 155-161 0341-2040 170:3<155 1992 170 408 https://doi.org/10.1007/BF00174318 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00174318 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Baganha M. Pneumology Service, University Hospital of Coimbra, 3000, Coimbra, Portugal aut NATIONALLICENCE 700 1- Mota-Pinto A. Immunology Laboratory, College of Medicine, University of Coimbra, 3000, Coimbra, Portugal aut NATIONALLICENCE 700 1- Pêgo M. Pneumology Service, University Hospital of Coimbra, 3000, Coimbra, Portugal aut NATIONALLICENCE 700 1- Marques M. Pneumology Service, University Hospital of Coimbra, 3000, Coimbra, Portugal aut NATIONALLICENCE 700 1- Santos Rosa M. Immunology Laboratory, College of Medicine, University of Coimbra, 3000, Coimbra, Portugal aut NATIONALLICENCE 700 1- Robalo Cordeiro A. Pneumology Service, University Hospital of Coimbra, 3000, Coimbra, Portugal aut NATIONALLICENCE 773 0- Lung Springer-Verlag 170/3(1992-05-01), 155-161 0341-2040 170:3<155 1992 170 408 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer