caa a22 4500 469049111 CHVBK 20180323132825.0 cr unu---uuuuu 170328e19920701xx s 000 0 eng 10.1007/BF00174119 doi (NATIONALLICENCE)springer-10.1007/BF00174119 Expression of the CD11/CD18 cell surface adhesion glycoprotein family and MHC class II antigen on blood monocytes and alveolar macrophages in interstitial lung diseases [Elektronische Daten] [Henk Hoogsteden, Peter van Hal, Johanna Wijkhuijs, Wim Hop, Chris Hilveringi] The expression of molecules of the CD 11/CD18 cell surface adhesion glycoprotein family and HLA/DR antigen was studied on peripheral blood monocytes (PBM) and alveolar macrophages (AM) in bronchoalveolar lavage (BAL) fluid from patients with sarcoidosis, idiopathic pulmonary fibrosis (IPF), and extrinsic allergic alveolitis (EAA). Patients with these interstitial lung diseases showed increased numbers of macrophages in BAL fluid. This was probably caused by an increased influx of PBM to the alveoli since the numbers of cells with a monocytic morphology were also significantly increased in BAL samples from patients with interstitial lung disease, most prominently in IPF and EAA. The increased influx of PBM into the alveoli in patients with interstitial lung diseases was not reflected by an increased expression of the CD11/CD18 leukocyte function antigens on PBM. In healthy volunteers as well as in those with sarcoidosis, IPF, and EAA, the percentages of AM positive for CD11b (the C3bi complement receptor) and CD11c were lower than among PBM. This indicates that the expression of these cell surface adhesion molecules is downregulated during maturation and migration of PBM to the alveoli. The absolute numbers of AM positive for CD11b were increased in BAL fluid of IPF and EAA patients compared to healthy volunteers. EAA patients also showed increased absolute numbers of AM positive for CD11a and CD11c. This differentially increased expression of these leukocyte function antigens on AM suggests the influence of locally produced cytokines. Springer-Verlag, 1992 Monocytes nationallicence Macrophages nationallicence Interstitial lung disease nationallicence Bronchoalveolar lavage nationallicence Leukocyte function antigens nationallicence Hoogsteden Henk Departments of Pulmonary Medicine, University Hospital Dijkzigt and the Erasmus University, Dr. Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands aut van Hal Peter Departments of Pulmonary Medicine Immunology, University Hospital Dijkzigt and the Erasmus University, Dr. Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands aut Wijkhuijs Johanna Departments of Pulmonary Medicine Immunology, University Hospital Dijkzigt and the Erasmus University, Dr. Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands aut Hop Wim Departments of Pulmonary Medicine Biostatistics, University Hospital Dijkzigt and the Erasmus University, Dr. Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands aut Hilveringi Chris Departments of Pulmonary Medicine, University Hospital Dijkzigt and the Erasmus University, Dr. Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands aut Lung Springer-Verlag 170/4(1992-07-01), 221-233 0341-2040 170:4<221 1992 170 408 https://doi.org/10.1007/BF00174119 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00174119 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hoogsteden Henk Departments of Pulmonary Medicine, University Hospital Dijkzigt and the Erasmus University, Dr. Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands aut NATIONALLICENCE 700 1- van Hal Peter Departments of Pulmonary Medicine Immunology, University Hospital Dijkzigt and the Erasmus University, Dr. Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands aut NATIONALLICENCE 700 1- Wijkhuijs Johanna Departments of Pulmonary Medicine Immunology, University Hospital Dijkzigt and the Erasmus University, Dr. Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands aut NATIONALLICENCE 700 1- Hop Wim Departments of Pulmonary Medicine Biostatistics, University Hospital Dijkzigt and the Erasmus University, Dr. Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands aut NATIONALLICENCE 700 1- Hilveringi Chris Departments of Pulmonary Medicine, University Hospital Dijkzigt and the Erasmus University, Dr. Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands aut NATIONALLICENCE 773 0- Lung Springer-Verlag 170/4(1992-07-01), 221-233 0341-2040 170:4<221 1992 170 408 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer