caa a22 4500 469049138 CHVBK 20180323132825.0 cr unu---uuuuu 170328e19920701xx s 000 0 eng 10.1007/BF00174120 doi (NATIONALLICENCE)springer-10.1007/BF00174120 Later development of asthma in patients with a negative methacholine inhalation challenge examined for suspected asthma [Elektronische Daten] [Hannu Puolijoki, Olli Impivaara, Kari Liippo, Eero Tala] A negative methacholine inhalation challenge (MIC) in a patient with suspected bronchial asthma is generally considered to make this diagnosis unlikely. Nevertheless, the patient may later develop asthma. To estimate the proportion that eventually becomes asthmatic, a 10 year follow-up study was carried out on 334 consecutive MIC-negative patients aged 14-80 years. The development of asthma among these patients was assessed on the basis of entitlement to preferential refund from the cost of antiasthmatic therapy granted for them under national health insurance. During the follow-up 30 patients (9%) were granted the refund. There was no significant difference between men and women in this respect. Patients who developed asthma were somewhat older than those who did not. A family history of allergy, allergic rhinitis, and positive reactions to skin prick tests were significantly more common in patients with future asthma. These patients also had a lower mean forced expiratory volume in 1 sec (FEV1) (% of predicted) and a higher mean increase in PEF after an inhaled sympathomimetic than those remaining free from asthma. In multivariate analyses with a logistic model, 3 risk indicators proved independent predictors of future asthma: age, positive family history of allergy, and FEV, (% of predicted). Springer-Verlag, 1992 Clinical examinations nationallicence Epidemiologic methods nationallicence Follow-up studies nationallicence Hypersensitivity nationallicence Lung volume measurements nationallicence Puolijoki Hannu Department of Diseases of the Chest, University Central Hospital, SF-21540, Preitilä, Finland aut Impivaara Olli Rehabilitation Research Centre of the Social Insurance Institution, Turku, Finland aut Liippo Kari Department of Diseases of the Chest, University Central Hospital, SF-21540, Preitilä, Finland aut Tala Eero Department of Diseases of the Chest, University Central Hospital, SF-21540, Preitilä, Finland aut Lung Springer-Verlag 170/4(1992-07-01), 235-241 0341-2040 170:4<235 1992 170 408 https://doi.org/10.1007/BF00174120 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00174120 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Puolijoki Hannu Department of Diseases of the Chest, University Central Hospital, SF-21540, Preitilä, Finland aut NATIONALLICENCE 700 1- Impivaara Olli Rehabilitation Research Centre of the Social Insurance Institution, Turku, Finland aut NATIONALLICENCE 700 1- Liippo Kari Department of Diseases of the Chest, University Central Hospital, SF-21540, Preitilä, Finland aut NATIONALLICENCE 700 1- Tala Eero Department of Diseases of the Chest, University Central Hospital, SF-21540, Preitilä, Finland aut NATIONALLICENCE 773 0- Lung Springer-Verlag 170/4(1992-07-01), 235-241 0341-2040 170:4<235 1992 170 408 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer