caa a22 4500 469049189 CHVBK 20180323132825.0 cr unu---uuuuu 170328e19920701xx s 000 0 eng 10.1007/BF00174117 doi (NATIONALLICENCE)springer-10.1007/BF00174117 Influence of azelastine and some selected drugs on mucociliary clearance [Elektronische Daten] [U. Achterrath-Tuckermann, V. Saano, E. Minker, F. Stroman, I. Arny, S. Joki, J. Nuutinen, I. Szelenyi] The effect of azelastine and some selected compounds on ciliary beating frequency (CBF) was investigated in vitro using human mucosal samples and in vivo using anesthetized guinea pigs. Further influence of azelastine on mucus secretion was evaluated in mice and on mucociliary clearance in anesthetized rabbits. Azelastine influenced the ciliary beating frequency neither in vitro nor in vivo. Azelastine, similarly to salbutamol, ambroxol, and bromhexine, increased mucus secretion measured by the tracheal output of phenol red. Azelastine dose-dependently enhanced mucociliary clearance measured by elimination of 99mTc-labeled erythrocytes in rabbits. The activity of azelastine proved to be about 10 times stronger than that of bromhexine. Since the ciliary activity remained unchanged under the influence of azelastine, it is likely that azelastine increases the mucociliary clearance by enhancing bronchial secretion. It is possible that the observed increase in mucociliary clearance may contribute to the beneficial effect of azelastine in the treatment of respiratory diseases. Springer-Verlag, 1992 Azelastine nationallicence Tracheobronchial secretion nationallicence Mucociliary clearance nationallicence Animal nationallicence Human mucosal explants nationallicence Achterrath-Tuckermann U. Department of Pharmacology, ASTA Pharma AG, POB 100105, D-6000, Frankfurt/M. 1, Germany aut Saano V. Departments of Pharmacology and Toxicology, University of Kuopio, POB. 6, SF-70211, Kuopio, Finland aut Minker E. Institute of Pharmacodynamics, Albert-Szent-Györgyi Medical University, POB 121, H-6701, Szeged, Hungary aut Stroman F. Department of Pharmacology, ASTA Pharma AG, POB 100105, D-6000, Frankfurt/M. 1, Germany aut Arny I. Department of Pharmacology, ASTA Pharma AG, POB 100105, D-6000, Frankfurt/M. 1, Germany aut Joki S. Institute of Pharmacodynamics, Albert-Szent-Györgyi Medical University, POB 121, H-6701, Szeged, Hungary aut Nuutinen J. Departments of Otorhinolaryngology, University of Kuopio, POB. 6, SF-70211, Kuopio, Finland aut Szelenyi I. Department of Pharmacology, ASTA Pharma AG, POB 100105, D-6000, Frankfurt/M. 1, Germany aut Lung Springer-Verlag 170/4(1992-07-01), 201-209 0341-2040 170:4<201 1992 170 408 https://doi.org/10.1007/BF00174117 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00174117 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Achterrath-Tuckermann U. Department of Pharmacology, ASTA Pharma AG, POB 100105, D-6000, Frankfurt/M. 1, Germany aut NATIONALLICENCE 700 1- Saano V. Departments of Pharmacology and Toxicology, University of Kuopio, POB. 6, SF-70211, Kuopio, Finland aut NATIONALLICENCE 700 1- Minker E. Institute of Pharmacodynamics, Albert-Szent-Györgyi Medical University, POB 121, H-6701, Szeged, Hungary aut NATIONALLICENCE 700 1- Stroman F. Department of Pharmacology, ASTA Pharma AG, POB 100105, D-6000, Frankfurt/M. 1, Germany aut NATIONALLICENCE 700 1- Arny I. Department of Pharmacology, ASTA Pharma AG, POB 100105, D-6000, Frankfurt/M. 1, Germany aut NATIONALLICENCE 700 1- Joki S. Institute of Pharmacodynamics, Albert-Szent-Györgyi Medical University, POB 121, H-6701, Szeged, Hungary aut NATIONALLICENCE 700 1- Nuutinen J. Departments of Otorhinolaryngology, University of Kuopio, POB. 6, SF-70211, Kuopio, Finland aut NATIONALLICENCE 700 1- Szelenyi I. Department of Pharmacology, ASTA Pharma AG, POB 100105, D-6000, Frankfurt/M. 1, Germany aut NATIONALLICENCE 773 0- Lung Springer-Verlag 170/4(1992-07-01), 201-209 0341-2040 170:4<201 1992 170 408 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer