caa a22 4500 469049219 CHVBK 20180323132825.0 cr unu---uuuuu 170328e19920901xx s 000 0 eng 10.1007/BF00566680 doi (NATIONALLICENCE)springer-10.1007/BF00566680 Influence of continuous positive airway pressure on sleep apnea-related desaturation in sleep apnea patients [Elektronische Daten] [F. Series, Y. Cormier, J. Laforge] To investigate the influence of nasal continuous positive airway pressure (CPAP) on apnea-related desaturation, we compared the sleep apnea-related desaturations obtained during a poly somnographic study before and during nasal CPAP in 15 sleep apnea patients. An individual desaturation curve was determined with a regression analysis by plotting the lowest SaO2 value reached during each apnea against its duration; these data were collected throughout the night. At baseline, we only considered the apneas with a preapneic SaO2 value greater than 90% and a minimal SaO2 value above or equal to 60%. For the CPAP study, the preapneic Sa02 value also had to be within 2% the baseline value for the apneas to be retained. Due to the restriction criteria imposed to characterize apnea-related Sa02 falls, residual apneas still had to be recorded with CPAP. These data were analyzed separately for obstructive apnea for non-rapid eye movement (REM) and REM sleep stages. A desaturation curve was obtained from 10 sec to a variable upper limit that corresponded to the longest apnea duration commonly reached during both baseline and CPAP for a given apnea-type and sleep stage. The individual apnea-related Sa02 fall was characterized by measuring a desaturation area corresponding to the area under the curve. It was expressed in % Sa02/sec of apnea. CPAP reduced the number of apneas per hour of sleep from 37.5 ± 6.5 (mean ± SEM) to 14.3 ∓ 3.7 (p = 0.001), and improved the whole night SaO2, level as estimated by a cumulative SaO2 curve. The mean apnea duration was reduced from 22.9 ± 1.5 sec at baseline to 16.8 ± 0.5 sec during CPAP therapy (p = 0.005). The preapneic SaO2 value was 94.8 ± 0.3% at baseline and 95.5 ± 0.2% during CPAP (p = 0.5). The desaturation area decreased from 267 ± 48% SaO2/sec at baseline to 152 ± 41% Sa02/sec during CPAP (p < 0.001). We conclude that CPAP improves the apnea-related desaturation independently of the shortening of apneas and of any difference in the preapneic SaO2 value. Springer-Verlag New York Inc., 1992 Desaturation curve nationallicence Apnea length nationallicence Oxygen stores nationallicence Lung volume nationallicence Sleep apnea nationallicence Series F. Unité de Recherche, Centre de Pneumologie de l'Hôpital Laval, Université Laval, 2725 Chemin Ste. Foy Ste Foy (PQ), GIV, 4135, Québec, Canada aut Cormier Y. Unité de Recherche, Centre de Pneumologie de l'Hôpital Laval, Université Laval, 2725 Chemin Ste. Foy Ste Foy (PQ), GIV, 4135, Québec, Canada aut Laforge J. Unité de Recherche, Centre de Pneumologie de l'Hôpital Laval, Université Laval, 2725 Chemin Ste. Foy Ste Foy (PQ), GIV, 4135, Québec, Canada aut Lung Springer-Verlag 170/5(1992-09-01), 281-290 0341-2040 170:5<281 1992 170 408 https://doi.org/10.1007/BF00566680 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00566680 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Series F. Unité de Recherche, Centre de Pneumologie de l'Hôpital Laval, Université Laval, 2725 Chemin Ste. Foy Ste Foy (PQ), GIV, 4135, Québec, Canada aut NATIONALLICENCE 700 1- Cormier Y. Unité de Recherche, Centre de Pneumologie de l'Hôpital Laval, Université Laval, 2725 Chemin Ste. Foy Ste Foy (PQ), GIV, 4135, Québec, Canada aut NATIONALLICENCE 700 1- Laforge J. Unité de Recherche, Centre de Pneumologie de l'Hôpital Laval, Université Laval, 2725 Chemin Ste. Foy Ste Foy (PQ), GIV, 4135, Québec, Canada aut NATIONALLICENCE 773 0- Lung Springer-Verlag 170/5(1992-09-01), 281-290 0341-2040 170:5<281 1992 170 408 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer