caa a22 4500 469049235 CHVBK 20180323132825.0 cr unu---uuuuu 170328e19920301xx s 000 0 eng 10.1007/BF00175980 doi (NATIONALLICENCE)springer-10.1007/BF00175980 Calcitonin gene-related peptide potentiates substance P-induced plasma extravasation in the rat trachea [Elektronische Daten] [James Brokaw, Gary White] Antidromic stimulation of vagal sensory nerves is known to produce plasma extravasation in the rat trachea. This neurogenic inflammation is thought to be mediated by substance P or other tachykinins released from sensory nerve endings. We sought to determine whether calcitonin gene-related peptide (CGRP), which is also released from sensory nerve endings, can potentiate substance P-induced plasma extravasation in the rat trachea. To accomplish this, we measured the amounts of Evans blue dye extravasated into the trachea after intravenous injections of substance P alone and combined with CGRP. We found that when substance P and CGRP were injected together, the amount of plasma extravasation produced in the trachea was substantially greater than the amount produced when substance P was injected alone. This potentiation was critically dependent on the dosage of CGRP and was not observed when relatively high dosages were used. We also found that CGRP had a potent hypotensive effect and speculate that reduced blood pressure may account for the lack of potentiation observed at the higher CGRP dosages. Based on these findings, we conclude that CGRP can potentiate substance P-induced plasma extravasation in the rat trachea and may therefore play a role in modulating neurogenic inflammation of the airways. Springer-Verlag, 1992 Neurogenic inflammation nationallicence Plasma extravasation nationallicence Substance P nationallicence Calcitonin gene-related peptide nationallicence Brokaw James Department of Anatomy, Indiana University School of Medicine, 1800 Lincoln Avenue, 47722, Evansville, IN, USA aut White Gary Department of Anatomy, Indiana University School of Medicine, 1800 Lincoln Avenue, 47722, Evansville, IN, USA aut Lung Springer-Verlag 170/2(1992-03-01), 85-93 0341-2040 170:2<85 1992 170 408 https://doi.org/10.1007/BF00175980 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00175980 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Brokaw James Department of Anatomy, Indiana University School of Medicine, 1800 Lincoln Avenue, 47722, Evansville, IN, USA aut NATIONALLICENCE 700 1- White Gary Department of Anatomy, Indiana University School of Medicine, 1800 Lincoln Avenue, 47722, Evansville, IN, USA aut NATIONALLICENCE 773 0- Lung Springer-Verlag 170/2(1992-03-01), 85-93 0341-2040 170:2<85 1992 170 408 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer