caa a22 4500 469049286 CHVBK 20180323132825.0 cr unu---uuuuu 170328e19920301xx s 000 0 eng 10.1007/BF02921340 doi (NATIONALLICENCE)springer-10.1007/BF02921340 Histamine in gastric carcinoid tumors: Immunocytochemical evidence [Elektronische Daten] [F. Sundler, B. Eriksson, L. Grimelius, R. Håkanson, H. Lönroth, L. Lundell] Gastric carcinoid tumors and nontumorous corpus mucosa from 4 patients suffering from chronic atrophic gastritis associated with pernicious anemia were characterized histochemically, with special reference to the cellular localization of histamine. Tissue sections were also examined for argentaffinity using the Masson technique, for argyrophilia using the Grimelius and Sevier-Munger techniques, and for chromogranin A and serotonin immunoreactivities. The majority of the tumor cells showed the staining characteristics of enterochromaffinlike cells: That is, they exhibited the argyrophil reaction with the Grimelius and Sevier-Munger techniques but lack of argentaffinity, positive histamine and chromogranin A immunostaining, but no serotonin immunoreactivity. Numerous histamine-immunoreactive mast cells were present in the stroma of the tumors and also in the surrounding mucosa. Our findings support the view that gastric carcinoids in patients with hypergastrinemia due to chronic atrophic gastritis are histamine-producing tumors derived from hyperplastic enterochromaffinlike cells. Humana Press Inc., 1992 Sundler F. Department of Medical Cell Research, University of Lund, Biskopsgatan 5, S-223 62, Lund, Sweden aut Eriksson B. Department of Surgery, Karolinska Hospital, Stockholm aut Grimelius L. Department of Pathology, University of Uppsala, Sweden aut Håkanson R. Department of Pharmacology, University of Lund, Lund aut Lönroth H. Department of Surgery, Sahlgren's Hospital, Gothenburg, Sweden aut Lundell L. Department of Surgery, Sahlgren's Hospital, Gothenburg, Sweden aut Endocrine Pathology Humana Press 3/1(1992-03-01), 23-27 1046-3976 3:1<23 1992 3 12022 https://doi.org/10.1007/BF02921340 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02921340 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sundler F. Department of Medical Cell Research, University of Lund, Biskopsgatan 5, S-223 62, Lund, Sweden aut NATIONALLICENCE 700 1- Eriksson B. Department of Surgery, Karolinska Hospital, Stockholm aut NATIONALLICENCE 700 1- Grimelius L. Department of Pathology, University of Uppsala, Sweden aut NATIONALLICENCE 700 1- Håkanson R. Department of Pharmacology, University of Lund, Lund aut NATIONALLICENCE 700 1- Lönroth H. Department of Surgery, Sahlgren's Hospital, Gothenburg, Sweden aut NATIONALLICENCE 700 1- Lundell L. Department of Surgery, Sahlgren's Hospital, Gothenburg, Sweden aut NATIONALLICENCE 773 0- Endocrine Pathology Humana Press 3/1(1992-03-01), 23-27 1046-3976 3:1<23 1992 3 12022 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer