caa a22 4500 469049383 CHVBK 20180323132826.0 cr unu---uuuuu 170328e19920901xx s 000 0 eng 10.1007/BF02921356 doi (NATIONALLICENCE)springer-10.1007/BF02921356 Colocalization of pancreatic polypeptide and insulin in secretory granules of a pancreatic endocrine neoplasm [Elektronische Daten] [Simon Raphael, N. Rodger, Doug B.S.] A 45-year-old woman presented with clinical symptoms of hypoglycemia of 4 months duration. Laboratory testing confirmed hyperinsulinemia; mild hypercalcemia and hypergastrine-mia were also documented. At the time of operation, 3 pancreatic endocrine neoplasms were found, and a diagnosis of multiple endocrine neoplasia type I was made. Immunohistochem-istry and immunoelectron microscopy showed all the tumors to be plurihormonal, each containing three or more of the following: insulin, glucagon, somatostatin, pancreatic polypep-tide, gastrin, and serotonin. Electron microscopy of 2 tumors revealed numerous atypical granules. In 1 tumor, pancreatic polypeptide and insulin were colocalized in secretory granules by dual-staining immunoelectron microscopy. To our knowledge, this combination of hormones has not been described previously in pancreatic endocrine neoplasms and suggests that such neoplasms, like mature pancreatic endocrine cells, may originate from pluripotential common precursor cells. Humana Press Inc., 1992 Raphael Simon Department of Pathology, St. Joseph's Hospital, 268 Grosvenor Street, N6A4L6, London, Ontario, Canada aut Rodger N. Department of Endocrinology, St. Joseph's Health Centre and University of Western Ontario, London, Ontario, Canada aut B.S. Doug Department of Pathology, St. Joseph's Hospital, 268 Grosvenor Street, N6A4L6, London, Ontario, Canada aut Endocrine Pathology Humana Press 3/3(1992-09-01), 152-159 1046-3976 3:3<152 1992 3 12022 https://doi.org/10.1007/BF02921356 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02921356 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Raphael Simon Department of Pathology, St. Joseph's Hospital, 268 Grosvenor Street, N6A4L6, London, Ontario, Canada aut NATIONALLICENCE 700 1- Rodger N. Department of Endocrinology, St. Joseph's Health Centre and University of Western Ontario, London, Ontario, Canada aut NATIONALLICENCE 700 1- B.S Doug Department of Pathology, St. Joseph's Hospital, 268 Grosvenor Street, N6A4L6, London, Ontario, Canada aut NATIONALLICENCE 773 0- Endocrine Pathology Humana Press 3/3(1992-09-01), 152-159 1046-3976 3:3<152 1992 3 12022 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer