caa a22 4500 469049391 CHVBK 20180323132826.0 cr unu---uuuuu 170328e19920901xx s 000 0 eng 10.1007/BF02921352 doi (NATIONALLICENCE)springer-10.1007/BF02921352 Adrenocortical neoplasms in childhood and adolescence: Analysis of prognostic factors including DNA content [Elektronische Daten] [Claudia Zerbini, Harry Kozakewich, David Weinberg, Diane Mundt, James Edwards, Ernest Lack] Thirty-two adrenocortical neoplasms in children and adolescents were evaluated for prognostic factors including clinical and morphological parameters and DNA ploidy. The patients were segregated into two groups according to clinical outcome: group A, represented by patients with clinically benign neoplasms (n = 15), and group B, patients with clinically malignant tumors as evidenced by local recurrence, metastases, or fatal outcome (n = 17). Clinical and morphological parameters in these two groups were evaluated using appropriate statistical methods. Parameters with a significant predictive value in terms of prognosis were age [p = .04], tumor size (p = .0003), median tumor weight (p = .0001), mitotic count (p = 0.04), and 25% tumor necrosis or more (p = .03). Twenty-three cases were studied for DNA ploidy: 10 cases by image analysis and 13 by both image analysis and flow cytometry. By ploidy analysis, 17 of 23 cases—12 of 14 in group A and 5 of 9 in group B—were found to be aneuploid. Multiple aneuploid peaks were found in 5 of 23 cases—4 of 14 cases in group A and 1 of 9 cases in group B. In tumors studied by both image analysis and flow cytometry, there was no discrepancy between results of ploidy analysis. There was no statistically significant association demonstrated between clinical outcome and DNA ploidy pattern. DNA ploidy heterogeneity, characterized by multiple aneuploid populations of cells, was also detected in both benign and malignant neoplasms. Based on our results, aneuploidy is relatively frequent in pediatrie adrenocortical tumors and does not appear to have predictive value for biological behavior. Humana Press Inc., 1992 Zerbini Claudia Department of Pathology, Children's Hospital, USA aut Kozakewich Harry Department of Pathology, Children's Hospital, USA aut Weinberg David Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA aut Mundt Diane Department of Biostatistics, Georgetown University School of Medicine, Washington, DC aut Edwards James Department of Pathology, Children's Hospital, USA aut Lack Ernest Department of Pathology, Georgetown University School of Medicine, Washington, DC aut Endocrine Pathology Humana Press 3/3(1992-09-01), 116-128 1046-3976 3:3<116 1992 3 12022 https://doi.org/10.1007/BF02921352 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02921352 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Zerbini Claudia Department of Pathology, Children's Hospital, USA aut NATIONALLICENCE 700 1- Kozakewich Harry Department of Pathology, Children's Hospital, USA aut NATIONALLICENCE 700 1- Weinberg David Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA aut NATIONALLICENCE 700 1- Mundt Diane Department of Biostatistics, Georgetown University School of Medicine, Washington, DC aut NATIONALLICENCE 700 1- Edwards James Department of Pathology, Children's Hospital, USA aut NATIONALLICENCE 700 1- Lack Ernest Department of Pathology, Georgetown University School of Medicine, Washington, DC aut NATIONALLICENCE 773 0- Endocrine Pathology Humana Press 3/3(1992-09-01), 116-128 1046-3976 3:3<116 1992 3 12022 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer