caa a22 4500 469049472 CHVBK 20180323132826.0 cr unu---uuuuu 170328e19921201xx s 000 0 eng 10.1007/BF02921361 doi (NATIONALLICENCE)springer-10.1007/BF02921361 Immunohistological studies for gastrointestinal and other hormones in acth-secreting adenomas [Elektronische Daten] [Theda Föller, Wolfgang Saeger, Dieter Lüdecke] Eighty-nine ACTH-secreting pituitary adenomas from patients with Cushing's disease or Nelson's syndrome were investigated by immunohistochemical methods for their content of gastrin, cholecystokinin (CCK), vasoactive intestinal peptide (VIP), bombesin, substance P, and ubiquitin as a marker for intercellular fibrils and hyalin and D11 as a marker for adrenocortical tissue. In contrast to in vitro studies reported in the relevant literature, we did not find significantly positive percentages (more than 10% of adenoma cells) for gastrin and CCK. VIP and bombesin were demonstrated in one adenoma. Among the adenomas examined, ubiquitin was found in 15% and D11 in 75%. ACTH was present in 99%, pro-γ-MSH in 21 %, β-endorphin in 13%, enkephalin in 4%, and α-subunit in 11.5%. The significance of the findings is discussed. Humana Press Inc., 1992 Föller Theda Department of Pathology, Marienkrankenhaus, Hamburg, Alfredstrasse 9, D-W 2000, Hamburg 76, Germany aut Saeger Wolfgang Department of Pathology, Marienkrankenhaus, Hamburg, Alfredstrasse 9, D-W 2000, Hamburg 76, Germany aut Lüdecke Dieter Department of Neurosurgery of the University of Hamburg, Germany aut Endocrine Pathology Humana Press 3/4(1992-12-01), 188-193 1046-3976 3:4<188 1992 3 12022 https://doi.org/10.1007/BF02921361 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02921361 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Föller Theda Department of Pathology, Marienkrankenhaus, Hamburg, Alfredstrasse 9, D-W 2000, Hamburg 76, Germany aut NATIONALLICENCE 700 1- Saeger Wolfgang Department of Pathology, Marienkrankenhaus, Hamburg, Alfredstrasse 9, D-W 2000, Hamburg 76, Germany aut NATIONALLICENCE 700 1- Lüdecke Dieter Department of Neurosurgery of the University of Hamburg, Germany aut NATIONALLICENCE 773 0- Endocrine Pathology Humana Press 3/4(1992-12-01), 188-193 1046-3976 3:4<188 1992 3 12022 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer