caa a22 4500 469049480 CHVBK 20180323132826.0 cr unu---uuuuu 170328e19921201xx s 000 0 eng 10.1007/BF02921362 doi (NATIONALLICENCE)springer-10.1007/BF02921362 Disseminated rectal carcinoid tumor with production of immunoreactive motilin [Elektronische Daten] [Knut Grönstad, Lars Grimelius, Rolf Ekman, Jan Kewenter, Håkan Ahlman] This report presents a patient with a rectal carcinoid tumor of small size ( 14 mm in diameter), with typical growth pattern, localized in the mucosa. Despite these microscopically good prognostic features the patient died from metastatic disease 30 months later. The tumor had an unusual hormone profile with main secretion of immunoreactive motilin and serotonin. Immunocytochemically these substances were localized in separate tumor cell populations; the majority of tumor cells were motilin-immunoreactive and a minority were serotonin-immunoreactive. The patient was first treated interventionally by hepatic arterial embolizations and later medically with octreotide. The treatment resulted in long periods of good palliation related to reduced levels of tumor markers and weight gain. The plasma concentrations of motilin were analyzed with a N-terminal-specific assay before and during treatment. Humana Press Inc., 1992 Grönstad Knut Department of Surgery, Sahlgrenska Hospital, University of Göteborg, S-413 45, Göteborg, Sweden aut Grimelius Lars Department of Pathology, University of Uppsala, Sweden aut Ekman Rolf Department of Psychiatry and Neurochemistry, University of Lund, Sweden aut Kewenter Jan Department of Surgery, Sahlgrenska Hospital, University of Göteborg, S-413 45, Göteborg, Sweden aut Ahlman Håkan Department of Surgery, Sahlgrenska Hospital, University of Göteborg, S-413 45, Göteborg, Sweden aut Endocrine Pathology Humana Press 3/4(1992-12-01), 194-200 1046-3976 3:4<194 1992 3 12022 https://doi.org/10.1007/BF02921362 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02921362 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Grönstad Knut Department of Surgery, Sahlgrenska Hospital, University of Göteborg, S-413 45, Göteborg, Sweden aut NATIONALLICENCE 700 1- Grimelius Lars Department of Pathology, University of Uppsala, Sweden aut NATIONALLICENCE 700 1- Ekman Rolf Department of Psychiatry and Neurochemistry, University of Lund, Sweden aut NATIONALLICENCE 700 1- Kewenter Jan Department of Surgery, Sahlgrenska Hospital, University of Göteborg, S-413 45, Göteborg, Sweden aut NATIONALLICENCE 700 1- Ahlman Håkan Department of Surgery, Sahlgrenska Hospital, University of Göteborg, S-413 45, Göteborg, Sweden aut NATIONALLICENCE 773 0- Endocrine Pathology Humana Press 3/4(1992-12-01), 194-200 1046-3976 3:4<194 1992 3 12022 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer