caa a22 4500 469049502 CHVBK 20180323132826.0 cr unu---uuuuu 170328e19920601xx s 000 0 eng 10.1007/BF02921346 doi (NATIONALLICENCE)springer-10.1007/BF02921346 The study of endocrine tumors by flow and image cytometry [Elektronische Daten] [Ingrid Zbieranowski, David Murray] Both DNA flow and image cytometry are methods that can be used for the quantitative determination of cellular DNA content. Objective, quantitative analysis of cellular morphology can also be obtained using image cytometry. Data thus generated have been shown to be of diagnostic and prognostic use in the study of many solid tumors and would be of particular value in the evaluation of endocrine tumors that show a poor correlation between their histology and biological behavior. The main application of these techniques to endocrine tumors has been in the analysis of thyroid nodules, although a limited number of studies of parathyroid, pituitary, adrenal, and pancreatic neuroendocrine tumors and tumors of the dispersed neuroendocrine system have been reported. Review of these studies shows that in the endocrine organs DNA and morphometric measurements have a very limited role in the diagnosis of individual cases, but are important as prognostic variables. The high incidence of abnormal DNA content in histologically benign lesions of the endocrine glands has important biological implications. Further investigation of this phenomenon may help to elucidate the process of endocrine tumorigenesis. Humana Press Inc., 1992 Zbieranowski Ingrid Department of Pathology, St. Michael's Hospital and University of Toronto, Toronto, Ontario, Canada aut Murray David Department of Pathology, St. Michael's Hospital and University of Toronto, Toronto, Ontario, Canada aut Endocrine Pathology Humana Press 3/2(1992-06-01), 63-82 1046-3976 3:2<63 1992 3 12022 https://doi.org/10.1007/BF02921346 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02921346 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Zbieranowski Ingrid Department of Pathology, St. Michael's Hospital and University of Toronto, Toronto, Ontario, Canada aut NATIONALLICENCE 700 1- Murray David Department of Pathology, St. Michael's Hospital and University of Toronto, Toronto, Ontario, Canada aut NATIONALLICENCE 773 0- Endocrine Pathology Humana Press 3/2(1992-06-01), 63-82 1046-3976 3:2<63 1992 3 12022 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer