caa a22 4500 469049510 CHVBK 20180323132826.0 cr unu---uuuuu 170328e19920601xx s 000 0 eng 10.1007/BF02921349 doi (NATIONALLICENCE)springer-10.1007/BF02921349 Hypothalamic neurocytoma with vasopressin immunoreactivity: Immunohistochemical and ultrastructural observations [Elektronische Daten] [John Maguire, Juan Bilbao, Kaiman Kovacs, Lothar Resch] Hypothalamic tumors of neuronal derivation are rare. We describe the case of a 55-year-old woman with visual disturbances who was found by magnetic resonance imaging (MRI) to have a sellar and suprasellar tumor. She underwent subtotal surgical resection by a transsphe-noidal approach. By light microscopy the tumor displayed a uniform population of short spindle cells with round to oval nuclei, separated by an abundant fibrillary stroma containing axonal processes as shown by the Bodian stain. The neoplastic cells were immunoreactive for neuron-specific enolase (NSE), synaptophysin, and vasopressin, and nonimmunoreactive for glial fibrillary acidic protein (GFAP), vasoactive intestinal peptide (VIP), bombesin, chromogranin, neurofilament, cytokeratins (high and low molecular weight), vimentin, S100 protein, somatostatin, β-endorphin, galactosamine, growth hormone-releasing hormone (GRH), neurophysin, serotonin, adrenaline and noradrenaline, and corticotropin-releasing hormone (CRH). Ultrastructural features included an abundance of neurosecretory granules within neurites and perinuclear cytoplasm. Synapses and glial stroma were not demonstrable. The term hypothalamic neurocytoma delineates this neuronal tumor with distinctive histologic, immunohistochemical, and ultrastructural features. The identification of vasopressin within the tumor provides evidence of neuroendocrine function. Humana Press Inc., 1992 Maguire John Department of Pathology, St. Michael's Hospital, 30 Bond Street, M5B 1W8, Toronto, Ontario, Canada aut Bilbao Juan Department of Pathology, St. Michael's Hospital, 30 Bond Street, M5B 1W8, Toronto, Ontario, Canada aut Kovacs Kaiman Department of Pathology, St. Michael's Hospital, 30 Bond Street, M5B 1W8, Toronto, Ontario, Canada aut Resch Lothar Department of Pathology, Dalhousie University, Halifax, Nova Scotia, Canada aut Endocrine Pathology Humana Press 3/2(1992-06-01), 99-104 1046-3976 3:2<99 1992 3 12022 https://doi.org/10.1007/BF02921349 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02921349 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Maguire John Department of Pathology, St. Michael's Hospital, 30 Bond Street, M5B 1W8, Toronto, Ontario, Canada aut NATIONALLICENCE 700 1- Bilbao Juan Department of Pathology, St. Michael's Hospital, 30 Bond Street, M5B 1W8, Toronto, Ontario, Canada aut NATIONALLICENCE 700 1- Kovacs Kaiman Department of Pathology, St. Michael's Hospital, 30 Bond Street, M5B 1W8, Toronto, Ontario, Canada aut NATIONALLICENCE 700 1- Resch Lothar Department of Pathology, Dalhousie University, Halifax, Nova Scotia, Canada aut NATIONALLICENCE 773 0- Endocrine Pathology Humana Press 3/2(1992-06-01), 99-104 1046-3976 3:2<99 1992 3 12022 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer