caa a22 4500 469049561 CHVBK 20180323132826.0 cr unu---uuuuu 170328e19920301xx s 000 0 eng 10.1007/BF02973990 doi (NATIONALLICENCE)springer-10.1007/BF02973990 Synthesis of substituted pyridine-2,4-dione nucleosides [Elektronische Daten] [Joon Lee, Jeong Won, Jung Park, Chang Hwang, K. Chung, Eung Ryu] The syntheses of novel heterocyclic base modified pyrimidine nucleosides are described. 5,6-Dimethyl-4-hydroxy-3-methoxy-1-(β-D-ribofuranosyl)-2(1H)-pyridinone7 was synthesized by condensation of silylated 5,6-dimethyl-4-hydroxy-3-methoxy-2(1H)-pyridinone with β-D-ribofuranose-1-acetate-2,3,5-tribenzoate in dichloroethane in the presence of Lewis acid followed by debenzoylation. The 2,2′-anhydro-5,6-dimethyl-2-hydroxy-3-methoxy-1-β-D-arabinofuranosyl-4-pyridinone8 was obtained from the reaction of the free ribonucleoside7 and diphenyl carbonate in DMF. None of these compounds showed any significant antiviral and antitumor activitiesin vitro tests. The Pharmaceutical Society of Korea, 1992 5,6-dimethyl-4-hydroxy-3-methoxy-2(1H)-pyridinone nationallicence 5,6-dimethyl-4-hydroxy-3-methoxy-1-(β-D-ribofuranosyl)-2(1H)-pyridinone nationallicence 2,2′-anhydro-5,6-dimethyl-2-hydroxy-3-methoxy-1-β-D-arabinofuranosyl-4-pyridinone nationallicence Lee Joon Department of Pharmacy, Chungbuk National University, 360-763, Cheong Ju, Korea aut Won Jeong Department of Pharmacy, Chungbuk National University, 360-763, Cheong Ju, Korea aut Park Jung Department of Pharmacy, Chungbuk National University, 360-763, Cheong Ju, Korea aut Hwang Chang Department of Pharmacy, Chungbuk National University, 360-763, Cheong Ju, Korea aut Chung K. Division of Organic Chemistry, Korea Research Institute of Chemical Technology, Daedeog-Danji, P.O. Box 9, 305-606, Taejon, Korea aut Ryu Eung Division of Organic Chemistry, Korea Research Institute of Chemical Technology, Daedeog-Danji, P.O. Box 9, 305-606, Taejon, Korea aut Archives of Pharmacal Research Pharmaceutical Society of Korea 15/1(1992-03-01), 87-90 0253-6269 15:1<87 1992 15 12272 https://doi.org/10.1007/BF02973990 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02973990 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lee Joon Department of Pharmacy, Chungbuk National University, 360-763, Cheong Ju, Korea aut NATIONALLICENCE 700 1- Won Jeong Department of Pharmacy, Chungbuk National University, 360-763, Cheong Ju, Korea aut NATIONALLICENCE 700 1- Park Jung Department of Pharmacy, Chungbuk National University, 360-763, Cheong Ju, Korea aut NATIONALLICENCE 700 1- Hwang Chang Department of Pharmacy, Chungbuk National University, 360-763, Cheong Ju, Korea aut NATIONALLICENCE 700 1- Chung K. Division of Organic Chemistry, Korea Research Institute of Chemical Technology, Daedeog-Danji, P.O. Box 9, 305-606, Taejon, Korea aut NATIONALLICENCE 700 1- Ryu Eung Division of Organic Chemistry, Korea Research Institute of Chemical Technology, Daedeog-Danji, P.O. Box 9, 305-606, Taejon, Korea aut NATIONALLICENCE 773 0- Archives of Pharmacal Research Pharmaceutical Society of Korea 15/1(1992-03-01), 87-90 0253-6269 15:1<87 1992 15 12272 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer