caa a22 4500 469049685 CHVBK 20180323132827.0 cr unu---uuuuu 170328e19920301xx s 000 0 eng 10.1007/BF02973992 doi (NATIONALLICENCE)springer-10.1007/BF02973992 Presence of acetylcholine-like substance(s) in Sesamum indicum [Elektronische Daten] [Anwar-ul Gilani, Khalid Aftab] Alcoholic extract of seeds ofSesamum indicum (SI, 1-30 mg/kg) caused hypotensive action in anesthetized rats. Heart rate was also decreased at slightly higher doses (10-30 mg/kg). Pretreatment with atropine (2 mg/kg) abolished these cardiovascular responses. In isolated spontaneously beating atria from guinea-pigs, SI caused decrease in force and rate of atrial contractions. In isolated guinea-pig ileum and rat uterus, SI (100-1000 ug/ml) produced contractile responses. All these actions of SI were abolished in the presence of atropine (1 μM). These results indicate that alcoholic extract of seeds ofSesamum indicum contains acetylcholine-like constituents(s) which explains some of the folkloric uses of plant. The Pharmaceutical Society of Korea, 1992 Sesamum indicum nationallicence seed extract nationallicence hypotensive nationallicence cholinergic nationallicence Gilani Anwar-ul Department of Pharmacology Medical College, The Aga Khan University, 74800, Karachi, Pakistan aut Aftab Khalid HEJ Research Institute of Chemistry, University of Karachi, Karachi, Pakistan aut Archives of Pharmacal Research Pharmaceutical Society of Korea 15/1(1992-03-01), 95-98 0253-6269 15:1<95 1992 15 12272 https://doi.org/10.1007/BF02973992 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02973992 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gilani Anwar-ul Department of Pharmacology Medical College, The Aga Khan University, 74800, Karachi, Pakistan aut NATIONALLICENCE 700 1- Aftab Khalid HEJ Research Institute of Chemistry, University of Karachi, Karachi, Pakistan aut NATIONALLICENCE 773 0- Archives of Pharmacal Research Pharmaceutical Society of Korea 15/1(1992-03-01), 95-98 0253-6269 15:1<95 1992 15 12272 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer