caa a22 4500 469049723 CHVBK 20180323132827.0 cr unu---uuuuu 170328e19920301xx s 000 0 eng 10.1007/BF02973994 doi (NATIONALLICENCE)springer-10.1007/BF02973994 Synthesis and biological activities of new substituted indoles [Elektronische Daten] [Orchidee Hishmat, Sally Nakkady, Osama El Shabrawy, Sawsan Mahmoud] 2,3-Diphenyl-6-formyl-5-methoxyindole reacts with ethyl cyano acetate to yield the arylidene derivative which forms with urea and thiourea the corresponding pyrimidine derivatives. The arylidene derivatives react with hydrazines and with active methylenes to form the respective pyrazole derivatives and the α, β-disubstituted acrylonitriles. Seven new compounds were tested for their effects on the arterial blood pressure of rats and analgesic activity. The Pharmaceutical Society of Korea, 1992 Indolyl pyrimidines nationallicence acrylonitriles nationallicence analgesics nationallicence arterial blood pressure effects nationallicence Hishmat Orchidee Natural Products Department, National Research Centre, Dokki, Egypt aut Nakkady Sally Natural Products Department, National Research Centre, Dokki, Egypt aut El Shabrawy Osama Pharmacology Department, National Research Centre, Dokki, Egypt aut Mahmoud Sawsan Pharmacology Department, National Research Centre, Dokki, Egypt aut Archives of Pharmacal Research Pharmaceutical Society of Korea 15/1(1992-03-01), 104-108 0253-6269 15:1<104 1992 15 12272 https://doi.org/10.1007/BF02973994 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02973994 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hishmat Orchidee Natural Products Department, National Research Centre, Dokki, Egypt aut NATIONALLICENCE 700 1- Nakkady Sally Natural Products Department, National Research Centre, Dokki, Egypt aut NATIONALLICENCE 700 1- El Shabrawy Osama Pharmacology Department, National Research Centre, Dokki, Egypt aut NATIONALLICENCE 700 1- Mahmoud Sawsan Pharmacology Department, National Research Centre, Dokki, Egypt aut NATIONALLICENCE 773 0- Archives of Pharmacal Research Pharmaceutical Society of Korea 15/1(1992-03-01), 104-108 0253-6269 15:1<104 1992 15 12272 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer