caa a22 4500 469049758 CHVBK 20180323132827.0 cr unu---uuuuu 170328e19920301xx s 000 0 eng 10.1007/BF02973993 doi (NATIONALLICENCE)springer-10.1007/BF02973993 El-Naggar Wael Department of Microbiology, Faculty of Pharmacy, Mansoura University, 35516, Mansoura, Egypt aut Effect of salicylate on antibacterial activity of different antibiotics [Elektronische Daten] [Wael El-Naggar] Susceptibility ofPseudomonas aeruginosa, Staphylococcus aureus, andBacillus subtilis to gentamicin and cefotaxime was affected by salicylaye. In presence of salicylaye (15 mM) and gentamicin (1.0 ug/ml), log efficiency of plating (log E.O.P.s) for the tested bacteria were −1.24, −2.17 and −1.66 respectively. The activity of cefotaxime againstBacillus subtilis was reduced (log E.O.P.=1.33). The highest potentiating effects of salicylaye were shown when using gentamicin againstStaphylococcus aureus, cefotaxime againstPs. aeruginosa, log E.O.P.s were −3.0, and −2.4, respectively. On the other hand, no significant effects were detected with cefotaxime againstStaphylococcus aureus (log E.O. P.=−0.04). No significant killing was shown in presence of gentamicin or salicylaye alone. There was no significant effect for salicylaye on MICs (By broth dilution) could be observed except in case of gentamicin againstStaphylococcus aureus, which was reduced from 0.02 ug/ml to 0.0012 ug/ml. These results raise the concern that high concentrations of salicylaye in patients might interfere with antibiotic therapies. The Pharmaceutical Society of Korea, 1992 Salicylate nationallicence efficiency of plating nationallicence gentamycin nationallicence cefotaxime nationallicence Archives of Pharmacal Research Pharmaceutical Society of Korea 15/1(1992-03-01), 99-103 0253-6269 15:1<99 1992 15 12272 https://doi.org/10.1007/BF02973993 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02973993 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- El-Naggar Wael Department of Microbiology, Faculty of Pharmacy, Mansoura University, 35516, Mansoura, Egypt aut NATIONALLICENCE 773 0- Archives of Pharmacal Research Pharmaceutical Society of Korea 15/1(1992-03-01), 99-103 0253-6269 15:1<99 1992 15 12272 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer