caa a22 4500 469049790 CHVBK 20180323132827.0 cr unu---uuuuu 170328e19920901xx s 000 0 eng 10.1007/BF02974066 doi (NATIONALLICENCE)springer-10.1007/BF02974066 The role of substituents of ar -turmerone for its anticancer activity [Elektronische Daten] [Won-Geun Oh, Kyong-Up Baik, Sang-Hun Jung, Byung-Zun Ahn] For the evaluation of the role of substituents ofar-turmerone for its anticancer activity, ar-turmerone (1a) and its analogs like 2-methyl-6-(4′-methyphenyl)-2-octen-4-one (1b), 2-methyl-6-phenyl-2-hepten-4-one (1c), 2-methyl-6-phenyl-2-octen-4-one, (1d), and 2-methyl-6-(trans-4′-methylcyclohexyl)-2-hepten-4-one (1e) were prepared and their cytotoxic activities against L1210 cell were determined. Omission of methyl group atpara-position dose not variate the cytotoxicity of ar-turmerone. Elongation of alkyl group at 6-position decreases ED50 value. Saturation of aromatic ring of ar-turmerone markedly decreases the cytotoxicity. Therefore the smaller size of alkyl group at 6-position and aromatic ring of ar-turmerone should be essential for exhibiting its anticancer activity. The Pharmaceutical Society of Korea, 1992 ar -turmerone nationallicence substituent effect nationallicence anticancer activity nationallicence cytotoxicity nationallicence Oh Won-Geun College of Pharmacy, Chung-Nam National University, Yousung Gu, 305-764, Dae Jeon, Korea aut Baik Kyong-Up College of Pharmacy, Chung-Nam National University, Yousung Gu, 305-764, Dae Jeon, Korea aut Jung Sang-Hun College of Pharmacy, Chung-Nam National University, Yousung Gu, 305-764, Dae Jeon, Korea aut Ahn Byung-Zun College of Pharmacy, Chung-Nam National University, Yousung Gu, 305-764, Dae Jeon, Korea aut Archives of Pharmacal Research Pharmaceutical Society of Korea 15/3(1992-09-01), 256-262 0253-6269 15:3<256 1992 15 12272 https://doi.org/10.1007/BF02974066 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02974066 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Oh Won-Geun College of Pharmacy, Chung-Nam National University, Yousung Gu, 305-764, Dae Jeon, Korea aut NATIONALLICENCE 700 1- Baik Kyong-Up College of Pharmacy, Chung-Nam National University, Yousung Gu, 305-764, Dae Jeon, Korea aut NATIONALLICENCE 700 1- Jung Sang-Hun College of Pharmacy, Chung-Nam National University, Yousung Gu, 305-764, Dae Jeon, Korea aut NATIONALLICENCE 700 1- Ahn Byung-Zun College of Pharmacy, Chung-Nam National University, Yousung Gu, 305-764, Dae Jeon, Korea aut NATIONALLICENCE 773 0- Archives of Pharmacal Research Pharmaceutical Society of Korea 15/3(1992-09-01), 256-262 0253-6269 15:3<256 1992 15 12272 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer