caa a22 4500 469049804 CHVBK 20180323132827.0 cr unu---uuuuu 170328e19920901xx s 000 0 eng 10.1007/BF02974067 doi (NATIONALLICENCE)springer-10.1007/BF02974067 The synthesis and antimicrobial activities of some 1,4-naphthoquinones (II) [Elektronische Daten] [Chung-Kyu Ryu, Dong-Hyun Kim] In order to evaluate the antimicrobial effect of 2,3-disubstituted-1,4-naphthoquinone derivatives we newly synthesized several 2-chloro and 2-bromo-3-(substituted)-1,4-naphthoquninones. Amination reaction of 2,3-dihalo-1,4-naphthoquinones with aryl and aliphatic amines in ethanol gave 2-halo-3-(N-alkyl or N-aryl)-1,4-naphthoquinone derivatives (1a,b-10a,b) in 60%-90% yield. These derivatives subjected to antibacterial and antifungal activities,in vitro, againstBacillus subtilis ATCC 6633, Candida albicans 10231 and local, Pseudomonas aeruginosa NCTC10490, Staphylococcus aureus ATCC 6538p, Escherichia coli NIHJ, Aspergillus niger KCTC 1231. Tricophyton mentagrophytes KCTC 6085. Among these derivatives,1b, 6b and7a showed the potent antibacterial activities.1b, 8b and9b have the antifungal activities.1b is most effective in preventing the growth ofBacillus subtilis and Pseudomonas aeruginosa, Candida albicans, Aspergillus niger. Tricophyton mentagrophytes. The several of these compounds demonstrated a broad spectrum of activitiesin vitro. The Pharmaceutical Society of Korea, 1992 2-chloro-and 2-bromo-3-(substituted)-1,4-naphthoquinone nationallicence aromatic and aliphatic amine nationallicence substitution nationallicence antifungal nationallicence antibacterial activities nationallicence Ryu Chung-Kyu College of Pharmacy, Ewha Womans University, 120-750, Seoul, Korea aut Kim Dong-Hyun College of Pharmacy, Kyung Hee University, Seoul aut Archives of Pharmacal Research Pharmaceutical Society of Korea 15/3(1992-09-01), 263-268 0253-6269 15:3<263 1992 15 12272 https://doi.org/10.1007/BF02974067 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02974067 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ryu Chung-Kyu College of Pharmacy, Ewha Womans University, 120-750, Seoul, Korea aut NATIONALLICENCE 700 1- Kim Dong-Hyun College of Pharmacy, Kyung Hee University, Seoul aut NATIONALLICENCE 773 0- Archives of Pharmacal Research Pharmaceutical Society of Korea 15/3(1992-09-01), 263-268 0253-6269 15:3<263 1992 15 12272 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer