caa a22 4500 46904988X CHVBK 20180323132827.0 cr unu---uuuuu 170328e19920901xx s 000 0 eng 10.1007/BF02974064 doi (NATIONALLICENCE)springer-10.1007/BF02974064 Multiple plasma peaks of acetaminophen and ranitidine after simultaneous oral administration to rats [Elektronische Daten] [Chang-Koo Shim, Mi-Kyung Suh] Acetaminophen (AAP) and ranitidine (RT) were coadministered orally to nine rats, and the possible contribution of the gastric emptying to the plasma concentration profiles of them was examined. The drugs showed multiple plasma peaks similar to the respective ones after separated administration of each durg. It implies that there is no significant interaction between AAP and RT in terms of the gastric emptying or drug absorption. There were no significant linear correlations of the peak patterns (peak height and peak time) between AAP andd RT. It is contrary to the expectation from the biphasic gastric emptying (BGE) theory previously suggested for AAP and RT. The BGE theory, therefore, seemed to have some draw-backs in explaining satisfactorily the multiple plasma peaks of AAP and RT. Two more doubts raised previously against the BGE theory were also discussed. The Pharmaceutical Society of Korea, 1992 Multiple plasma peaks nationallicence acetaminophen (AAP) nationallicence ranitidine (RT) nationallicence biphasic gastric emptying (BGE) nationallicence simultaneous administration nationallicence Shim Chang-Koo College of Pharmacy, Seoul National University, San 56-1, Shinlim-Dong, Kwanak-Gu, 151-742, Seoul, Korea aut Suh Mi-Kyung College of Pharmacy, Seoul National University, San 56-1, Shinlim-Dong, Kwanak-Gu, 151-742, Seoul, Korea aut Archives of Pharmacal Research Pharmaceutical Society of Korea 15/3(1992-09-01), 246-250 0253-6269 15:3<246 1992 15 12272 https://doi.org/10.1007/BF02974064 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02974064 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Shim Chang-Koo College of Pharmacy, Seoul National University, San 56-1, Shinlim-Dong, Kwanak-Gu, 151-742, Seoul, Korea aut NATIONALLICENCE 700 1- Suh Mi-Kyung College of Pharmacy, Seoul National University, San 56-1, Shinlim-Dong, Kwanak-Gu, 151-742, Seoul, Korea aut NATIONALLICENCE 773 0- Archives of Pharmacal Research Pharmaceutical Society of Korea 15/3(1992-09-01), 246-250 0253-6269 15:3<246 1992 15 12272 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer