caa a22 4500 469049898 CHVBK 20180323132827.0 cr unu---uuuuu 170328e19920901xx s 000 0 eng 10.1007/BF02974063 doi (NATIONALLICENCE)springer-10.1007/BF02974063 Antiviral triterpenes from Prunella vulgaris [Elektronische Daten] [Shi Ryu, Chong-Kyo Lee, Chong Lee, Hae Kim, Ok Zee] Two triterpenes 1 and 2 with antiviral activity againstHerpes simplex virus type 1in vitro were isolated fromPrunella vulgaris. Each compound caused a significant reduction in viral cytopathic effect whenvero cells were exposed to them for 72 hours after viral challenge. They were identified asbetulinic acid(1) and 2α, 3α-dihydroxyurs-12-en-28-oic acid(2) on the basis of their spectroscopic properties. The antiviral activity of them was estimated as EC50=30 μg/ml(1) and 8 μg/ml(2), respectively by plaque reduction assay. The Pharmaceutical Society of Korea, 1992 Prunella vulgaris nationallicence Labiatae nationallicence betulinic acid nationallicence 2α,3α-dihydroxyurs-12-en-28-oic acid nationallicence antiviral nationallicence Herpes simplex nationallicence Ryu Shi Korea Research Institute of Chemical Technology, 305-606, Taejeon, Korea aut Lee Chong-Kyo Korea Research Institute of Chemical Technology, 305-606, Taejeon, Korea aut Lee Chong Korea Research Institute of Chemical Technology, 305-606, Taejeon, Korea aut Kim Hae Korea Research Institute of Chemical Technology, 305-606, Taejeon, Korea aut Zee Ok Korea Research Institute of Chemical Technology, 305-606, Taejeon, Korea aut Archives of Pharmacal Research Pharmaceutical Society of Korea 15/3(1992-09-01), 242-245 0253-6269 15:3<242 1992 15 12272 https://doi.org/10.1007/BF02974063 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02974063 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ryu Shi Korea Research Institute of Chemical Technology, 305-606, Taejeon, Korea aut NATIONALLICENCE 700 1- Lee Chong-Kyo Korea Research Institute of Chemical Technology, 305-606, Taejeon, Korea aut NATIONALLICENCE 700 1- Lee Chong Korea Research Institute of Chemical Technology, 305-606, Taejeon, Korea aut NATIONALLICENCE 700 1- Kim Hae Korea Research Institute of Chemical Technology, 305-606, Taejeon, Korea aut NATIONALLICENCE 700 1- Zee Ok Korea Research Institute of Chemical Technology, 305-606, Taejeon, Korea aut NATIONALLICENCE 773 0- Archives of Pharmacal Research Pharmaceutical Society of Korea 15/3(1992-09-01), 242-245 0253-6269 15:3<242 1992 15 12272 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer