caa a22 4500 469049952 CHVBK 20180323132827.0 cr unu---uuuuu 170328e19921201xx s 000 0 eng 10.1007/BF02974104 doi (NATIONALLICENCE)springer-10.1007/BF02974104 Effect of lipid peroxidation on the fluidity of erythrocyte ghost and phospholipid liposomal membranes [Elektronische Daten] [Suk Han, Min Kim, Yeong Park, Eun Park, Jeong Lee] The effects of lipid peroxidation on the fluidity of the lipid bilayers of the human erythrocyte ghosts and egg-lecithin phospholipid liposomes have been studied. For the measurements of the peroxidation extent and the fluidity of the membranes, the thiobarbituric acid-reactive substances and the fluorescence depolarization of 1,6-diphenyl-1,3,5-hexatriene labelled into the membrane were employed, respectively. The lipid peroxidation was performed in hypoxanthine/xanthine oxidase/ferrous ion, and hydrogen peroxide/ferrous ion systems. The results of these experiments show that both of the xanthine oxidase and hydrogen peroxide systems effectively induced the lipid peroxidation of the ghosts, and the liposomal membranes, respectively. The lipid peroxidation decreased the fluidity of the, membranes, especially at the very early stage of the peroxidation reaction. The decrease in the fluidity of membrane by the lipid peroxidation has been ascribed to the alteration of the polyunsaturated acyl chains of lipids and cross-linkings among the membrane components. However, under drastic condition of lipid peroxidation, the fluidity of the membrane rather increased possibly due to the deterioration of the membrane integrity by the peroxidation. Morphological change of the erythrocyte on peroxidation has also been observed. The Pharmaceutical Society of Korea, 1992 Lipid peroxidation nationallicence fluidity of membranes nationallicence erythrocyte ghosts nationallicence liposomes nationallicence fluorescence polarization nationallicence morphology nationallicence Han Suk College of Pharmacy, Pusan National University, 609-735, Pusan, Korea aut Kim Min College of Pharmacy, Pusan National University, 609-735, Pusan, Korea aut Park Yeong College of Pharmacy, Pusan National University, 609-735, Pusan, Korea aut Park Eun College of Pharmacy, Pusan National University, 609-735, Pusan, Korea aut Lee Jeong College of Pharmacy, Pusan National University, 609-735, Pusan, Korea aut Archives of Pharmacal Research Pharmaceutical Society of Korea 15/4(1992-12-01), 309-316 0253-6269 15:4<309 1992 15 12272 https://doi.org/10.1007/BF02974104 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02974104 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Han Suk College of Pharmacy, Pusan National University, 609-735, Pusan, Korea aut NATIONALLICENCE 700 1- Kim Min College of Pharmacy, Pusan National University, 609-735, Pusan, Korea aut NATIONALLICENCE 700 1- Park Yeong College of Pharmacy, Pusan National University, 609-735, Pusan, Korea aut NATIONALLICENCE 700 1- Park Eun College of Pharmacy, Pusan National University, 609-735, Pusan, Korea aut NATIONALLICENCE 700 1- Lee Jeong College of Pharmacy, Pusan National University, 609-735, Pusan, Korea aut NATIONALLICENCE 773 0- Archives of Pharmacal Research Pharmaceutical Society of Korea 15/4(1992-12-01), 309-316 0253-6269 15:4<309 1992 15 12272 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer