caa a22 4500 469050012 CHVBK 20180323132828.0 cr unu---uuuuu 170328e19921201xx s 000 0 eng 10.1007/BF02974098 doi (NATIONALLICENCE)springer-10.1007/BF02974098 Brazilin inhibits mitogen induced cell proliferation despite of augmentation of T cell growth factor(TCGF) production and expression of IL-2 receptors [Elektronische Daten] [Chang-Kiu Moon, Myung-Soo Mock, Kyung-Mee Yang, Cheol-Hong Lim, Kang-Seok Kim, Jin-Ho Chung, Chang-Hyun Moon] The present work was designed to investigate the effects of brazilin on ConA-induced TCGF release, responsiveness to standard IL-2, and mitogens-induced proliferation of splenocyte when administered intraperitoneally to 8 week-old C57BL/6 mice for 2 consecutive days. Immunological tests were performed 72 hours after the treatment of brazilin. The administration of 50 mg/kg brazilin caused a noticeable increase in TCGF release and responsiveness to standard IL-2, but inhibited mitogens-induced proliferation of splenocyte. These results indicated that brazilin is able to modulate immunological functions despite of its inhibitory effect on mitogen induced cell proliferation. The Pharmaceutical Society of Korea, 1992 Brazilin nationallicence immunomodulation nationallicence TCGF nationallicence responsiveness to IL-2 nationallicence lymphocyte proliferation nationallicence Moon Chang-Kiu College of Pharmacy, Seoul National University, 151-742, Seoul, Korea aut Mock Myung-Soo College of Pharmacy, Seoul National University, 151-742, Seoul, Korea aut Yang Kyung-Mee College of Pharmacy, Seoul National University, 151-742, Seoul, Korea aut Lim Cheol-Hong College of Pharmacy, Seoul National University, 151-742, Seoul, Korea aut Kim Kang-Seok College of Pharmacy, Seoul National University, 151-742, Seoul, Korea aut Chung Jin-Ho College of Pharmacy, Seoul National University, 151-742, Seoul, Korea aut Moon Chang-Hyun School of Medicine, Ajou University, 440-649, Soowon, Korea aut Archives of Pharmacal Research Pharmaceutical Society of Korea 15/4(1992-12-01), 275-282 0253-6269 15:4<275 1992 15 12272 https://doi.org/10.1007/BF02974098 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02974098 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Moon Chang-Kiu College of Pharmacy, Seoul National University, 151-742, Seoul, Korea aut NATIONALLICENCE 700 1- Mock Myung-Soo College of Pharmacy, Seoul National University, 151-742, Seoul, Korea aut NATIONALLICENCE 700 1- Yang Kyung-Mee College of Pharmacy, Seoul National University, 151-742, Seoul, Korea aut NATIONALLICENCE 700 1- Lim Cheol-Hong College of Pharmacy, Seoul National University, 151-742, Seoul, Korea aut NATIONALLICENCE 700 1- Kim Kang-Seok College of Pharmacy, Seoul National University, 151-742, Seoul, Korea aut NATIONALLICENCE 700 1- Chung Jin-Ho College of Pharmacy, Seoul National University, 151-742, Seoul, Korea aut NATIONALLICENCE 700 1- Moon Chang-Hyun School of Medicine, Ajou University, 440-649, Soowon, Korea aut NATIONALLICENCE 773 0- Archives of Pharmacal Research Pharmaceutical Society of Korea 15/4(1992-12-01), 275-282 0253-6269 15:4<275 1992 15 12272 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer