caa a22 4500 469050187 CHVBK 20180323132828.0 cr unu---uuuuu 170328e19920601xx s 000 0 eng 10.1007/BF02974094 doi (NATIONALLICENCE)springer-10.1007/BF02974094 Lymphoblastosis inhibition and plaque-forming cell response of several anti-inflammatory steroids in mice [Elektronische Daten] [Hong Choi, Kilhyoun Kim, Hyun Kim] Anti-inflammatory glucocorticoid (GC) derivatives have been clinically used in immune-malfunctional diseases for their immunosuppressive activity. However, there is still a lack of knowledge on the relationship between anti-inflammatory and immuno-suppressive activities. In order to compare immunosuppressive activities with the known anti-inflammatory activities of the GC derivatives, eight clinically used GC derivatives including hydrocortisone, prednisolone, 6α-methyl prednisolone, triamcinolone, dexamethasone, betamethasone, triamcinolone acetonide and fluocinolone acetonide were selected, and lymphoblastosis inhibition and plaque-forming cell (PFC) response in mice were studied as immunological parameters. In Con A-induced lymphoblastosis inhibitionin vitro, all derivatives showed potent inhibition. IC50 values of the derivatives except methyl prednisolone and triamcinolone were less than 10−7M and good dose dependency was obtained. This result was well correlated with that of their anti-inflammatory potencies and their receptor binding affinities. However, in PFC response, consistent results were not obtained. Total numbers of PFCs per spleen were decreased by some derivatives, but numbers of PFCs per 106 cells were not decreased by systemic administration of GC at the dose of 0.05 mg/mouse. Furthermore, at the dose of 0.1 mg/mouse, numbers of PFCs per 106 cells were found to be increased, although total PFCs per spleen were decreased. The Pharmaceutical Society of Korea, 1992 Glucocorticoid nationallicence steroid nationallicence anti-inflammation nationallicence immunosuppression nationallicence receptor binding affinity nationallicence lymphoblastosis inhibition nationallicence plaque-forming cell nationallicence Choi Hong College of Pharmacy, Kangweon National University, 200-701, Chuncheon aut Kim Kilhyoun Genetic Engineering Research Institute, P.O. Box 17, 305-606, Taejeon, Korea aut Kim Hyun College of Pharmacy, Kangweon National University, 200-701, Chuncheon aut Archives of Pharmacal Research Pharmaceutical Society of Korea 15/2(1992-06-01), 169-175 0253-6269 15:2<169 1992 15 12272 https://doi.org/10.1007/BF02974094 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02974094 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Choi Hong College of Pharmacy, Kangweon National University, 200-701, Chuncheon aut NATIONALLICENCE 700 1- Kim Kilhyoun Genetic Engineering Research Institute, P.O. Box 17, 305-606, Taejeon, Korea aut NATIONALLICENCE 700 1- Kim Hyun College of Pharmacy, Kangweon National University, 200-701, Chuncheon aut NATIONALLICENCE 773 0- Archives of Pharmacal Research Pharmaceutical Society of Korea 15/2(1992-06-01), 169-175 0253-6269 15:2<169 1992 15 12272 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer