caa a22 4500 469050268 CHVBK 20180323132828.0 cr unu---uuuuu 170328e19920601xx s 000 0 eng 10.1007/BF02974084 doi (NATIONALLICENCE)springer-10.1007/BF02974084 Biological monitoring of human exposure to volatile halogenated hydrocarbons using urinalysis with capillary GC-ECD [Elektronische Daten] [Won Jung, Dong Sohn] For the risk assessment of human exposure to volatile halogenated hydrocarbons, a dynamic purge trap/on-column cryofocusing method using capillary gas chromatograph-63Ni electron capture detector and thermal desorption unit was applied to analyze the free forms, metabolites of 1,1,2-trichloroethylene and 1,1,2,2-tetrachloroethylene. The urine sample was diluted with distilled water, hydrolyzed and sealed. Then the inert gas was infused to purge out free 1,1,2-trichloroethylene, free 1,1,2,2-tetrachloroethylene and trichloroethanol. These compounds were trapped to TenaxR GC-gas trap device throughout clean up tube. Being undetectable to gas chromatograph directly, trichloroacetic acid was methyl esterificated and trapped in the manner above mentioned. The optimal incubation time to get best recovery of methyl ester was 4 hours at 60°C. The concentrations of free volatile halogenated hydrocarbons and their metabolites in urine were obtained from 5 healthy volunteers. This analytical method is expected to make the biological monitoring, more precise and convenient. The Pharmaceutical Society of Korea, 1992 Biological monitoring nationallicence volatile halogenated hydrocarbons nationallicence urinalysis nationallicence GC-ECD nationallicence purge trap/on-column cryofocusing method nationallicence Jung Won National Institute of Public Health, Shirokanedai 4-6-1, Minato, 108, Tokyo, Japan aut Sohn Dong College of Pharmacy, Chungang University, 156-070, Seoul, Korea aut Archives of Pharmacal Research Pharmaceutical Society of Korea 15/2(1992-06-01), 109-114 0253-6269 15:2<109 1992 15 12272 https://doi.org/10.1007/BF02974084 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02974084 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Jung Won National Institute of Public Health, Shirokanedai 4-6-1, Minato, 108, Tokyo, Japan aut NATIONALLICENCE 700 1- Sohn Dong College of Pharmacy, Chungang University, 156-070, Seoul, Korea aut NATIONALLICENCE 773 0- Archives of Pharmacal Research Pharmaceutical Society of Korea 15/2(1992-06-01), 109-114 0253-6269 15:2<109 1992 15 12272 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer