caa a22 4500 469050276 CHVBK 20180323132828.0 cr unu---uuuuu 170328e19920601xx s 000 0 eng 10.1007/BF02974095 doi (NATIONALLICENCE)springer-10.1007/BF02974095 Influence of various cyclodextrins on the stability of hydrocortisone 17-butyrate in aqueous solution [Elektronische Daten] [In Chun, Bo Kim] The stabilizing effects of α-, β-, γ- and dimethyl-β-cyclodextrins (α-, β-, γ-and DM-β-CyDs) on the degradation of hydrocortisone 17-butyrate (HC-17B) in aqueous solution was investigated. HC-17B underwent a facile hydroxide ion-catalyzed rearrangement to the less active 21-butyrate ester by the apparent first-order kinetics, and maximum stability of HC-17B was obtained at around, pH 4.0. The stability of HC-17B was increased by inclusion complexation with α-, γ- and DM-β-CyD in the pH range of 2.0-8.0 examined, whereas β-CyD accelerated the degradation of HC-17B at the pH higher than 5.0. The effects of ionic strength, solvent, temperature and CyD concentration were also investigated. Stability constants and apparent degradation rate constants of HC-17B-γ-CyD and HC-17B-DM-β-CyD complexes were determined kinetically on the basis of 1∶1 complexation. The results suggested that the inclusion complexation with γ-CyD or DM-β-CyD was most useful means to enhance the stability of the steroid. The Pharmaceutical Society of Korea, 1992 Hydrocortisone butyrate nationallicence Cyclodextrins nationallicence Rearrangement nationallicence Stabilization nationallicence Inclusion complex nationallicence pH effect nationallicence Solvent nationallicence Ionic strength nationallicence Stability constant nationallicence Chun In Department of Pharmaceutics, College of Pharmacy, Dongduck Women's University, 136-714, Seoul, Korea aut Kim Bo Department of Pharmaceutics, College of Pharmacy, Dongduck Women's University, 136-714, Seoul, Korea aut Archives of Pharmacal Research Pharmaceutical Society of Korea 15/2(1992-06-01), 176-183 0253-6269 15:2<176 1992 15 12272 https://doi.org/10.1007/BF02974095 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02974095 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Chun In Department of Pharmaceutics, College of Pharmacy, Dongduck Women's University, 136-714, Seoul, Korea aut NATIONALLICENCE 700 1- Kim Bo Department of Pharmaceutics, College of Pharmacy, Dongduck Women's University, 136-714, Seoul, Korea aut NATIONALLICENCE 773 0- Archives of Pharmacal Research Pharmaceutical Society of Korea 15/2(1992-06-01), 176-183 0253-6269 15:2<176 1992 15 12272 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer