caa a22 4500 469053348 CHVBK 20180323132836.0 cr unu---uuuuu 170328e19921201xx s 000 0 eng 10.1007/BF00126214 doi (NATIONALLICENCE)springer-10.1007/BF00126214 Comparative molecular field analysis of CCK-A antagonists using field-fit as an alignment technique. A convenient guide to design new CCK-A ligands [Elektronische Daten] [Sylvain Rault, Ronan Bureau, Juan Pilo, Max Robba] Summary: Comparative molecular field analysis (CoMFA) has been used as a three-dimensional quantitative structure-activity relationship (QSAR) method to correlate the affinities of several antagonists towards CCK-A receptors with their steric and electrostatic fields. In this publication, we describe, for the first time, a field-fit operation as an alignment technique. These results could serve as a guide for the design of new non-peptide antagonists. ESCOM Science Publishers B.V, 1992 Cholecystokinin nationallicence CCK-A antagonists nationallicence Field-fit nationallicence Comparative molecular field analysis nationallicence Rault Sylvain Laboratoire de Chimie Thérapeutique, U.F.R. des Sciences Pharmaceutiques, 1 rue Vaubénard, 14032, Caen Cedex, France aut Bureau Ronan Laboratoire de Chimie Thérapeutique, U.F.R. des Sciences Pharmaceutiques, 1 rue Vaubénard, 14032, Caen Cedex, France aut Pilo Juan Laboratoire de Chimie Thérapeutique, U.F.R. des Sciences Pharmaceutiques, 1 rue Vaubénard, 14032, Caen Cedex, France aut Robba Max Laboratoire de Chimie Thérapeutique, U.F.R. des Sciences Pharmaceutiques, 1 rue Vaubénard, 14032, Caen Cedex, France aut Journal of Computer-Aided Molecular Design Kluwer Academic Publishers 6/6(1992-12-01), 553-568 0920-654X 6:6<553 1992 6 10822 https://doi.org/10.1007/BF00126214 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00126214 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Rault Sylvain Laboratoire de Chimie Thérapeutique, U.F.R. des Sciences Pharmaceutiques, 1 rue Vaubénard, 14032, Caen Cedex, France aut NATIONALLICENCE 700 1- Bureau Ronan Laboratoire de Chimie Thérapeutique, U.F.R. des Sciences Pharmaceutiques, 1 rue Vaubénard, 14032, Caen Cedex, France aut NATIONALLICENCE 700 1- Pilo Juan Laboratoire de Chimie Thérapeutique, U.F.R. des Sciences Pharmaceutiques, 1 rue Vaubénard, 14032, Caen Cedex, France aut NATIONALLICENCE 700 1- Robba Max Laboratoire de Chimie Thérapeutique, U.F.R. des Sciences Pharmaceutiques, 1 rue Vaubénard, 14032, Caen Cedex, France aut NATIONALLICENCE 773 0- Journal of Computer-Aided Molecular Design Kluwer Academic Publishers 6/6(1992-12-01), 553-568 0920-654X 6:6<553 1992 6 10822 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer