caa a22 4500 469054050 CHVBK 20180323132838.0 cr unu---uuuuu 170328e19920101xx s 000 0 eng 10.1007/BF01466270 doi (NATIONALLICENCE)springer-10.1007/BF01466270 Presence of atrial natriuretic factor and cyclic guanosine monophosphate in saliva. Comparison of plasma and salivary concentrations during a head-down tilt [Elektronische Daten] [G. Gauquelin, A. Maillet, A. Allevard, D. Vorobiev, A. Grigoriev, C. Gharib] Summary: Using a specific and sensitive radio-immunoassay involving separation and extraction procedures, we measured the concentration of saliva and plasma atrial natriuric factor (ANF) and cyclic guanosine monophosphate (cGMP) in men before and during a 10h head-down tilt at -6°. Saliva values closely correlated with plasma for ANF (r=0.7-0.95) and for cGMP (r=0.65-1). During this dynamic test, the mean concentrations of ANF and cGMP were significantly higher after 15 and 45 min, respectively, this increase persisting for 3.5 h. We concluded that the concentration of ANF in saliva may be significantly affected by a marked fluid shift from the lower to the upper half of the body. This is the first time that the presence of ANF and cGMP has been demonstrated in saliva. The great advantage of studying saliva is that it can be obtained non-invasively in athletes or during space flight. This methodology will be used during the Soviet-French space flight (Antares Project) planned for 1992. Springer-Verlag, 1992 Atrial natriuretic factor nationallicence Cyclic guanosine monophosphate nationallicence Saliva nationallicence Head-down tilt nationallicence Gauquelin G. Laboratoire de Physiologie de l'Environment, Faculté de Médecine Grange-Blanche, 8, Avenue Rockefeller, F-69373, Lyon Cedex 08, France aut Maillet A. Laboratoire de Physiologie de l'Environment, Faculté de Médecine Grange-Blanche, 8, Avenue Rockefeller, F-69373, Lyon Cedex 08, France aut Allevard A. Laboratoire de Physiologie de l'Environment, Faculté de Médecine Grange-Blanche, 8, Avenue Rockefeller, F-69373, Lyon Cedex 08, France aut Vorobiev D. Institute of Biomedical Problems, D7, Moscow, Russia aut Grigoriev A. Institute of Biomedical Problems, D7, Moscow, Russia aut Gharib C. Laboratoire de Physiologie de l'Environment, Faculté de Médecine Grange-Blanche, 8, Avenue Rockefeller, F-69373, Lyon Cedex 08, France aut European Journal of Applied Physiology and Occupational Physiology Springer-Verlag 65/1(1992-01-01), 25-29 0301-5548 65:1<25 1992 65 421 https://doi.org/10.1007/BF01466270 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01466270 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gauquelin G. Laboratoire de Physiologie de l'Environment, Faculté de Médecine Grange-Blanche, 8, Avenue Rockefeller, F-69373, Lyon Cedex 08, France aut NATIONALLICENCE 700 1- Maillet A. Laboratoire de Physiologie de l'Environment, Faculté de Médecine Grange-Blanche, 8, Avenue Rockefeller, F-69373, Lyon Cedex 08, France aut NATIONALLICENCE 700 1- Allevard A. Laboratoire de Physiologie de l'Environment, Faculté de Médecine Grange-Blanche, 8, Avenue Rockefeller, F-69373, Lyon Cedex 08, France aut NATIONALLICENCE 700 1- Vorobiev D. Institute of Biomedical Problems, D7, Moscow, Russia aut NATIONALLICENCE 700 1- Grigoriev A. Institute of Biomedical Problems, D7, Moscow, Russia aut NATIONALLICENCE 700 1- Gharib C. Laboratoire de Physiologie de l'Environment, Faculté de Médecine Grange-Blanche, 8, Avenue Rockefeller, F-69373, Lyon Cedex 08, France aut NATIONALLICENCE 773 0- European Journal of Applied Physiology and Occupational Physiology Springer-Verlag 65/1(1992-01-01), 25-29 0301-5548 65:1<25 1992 65 421 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer