caa a22 4500 46905428X CHVBK 20180323132839.0 cr unu---uuuuu 170328e19921101xx s 000 0 eng 10.1007/BF00602353 doi (NATIONALLICENCE)springer-10.1007/BF00602353 Marathon running: physiological and chemical changes accompanying late-race functional deterioration [Elektronische Daten] [Robert Cade, David Packer, Christian Zauner, David Kaufmann, John Peterson, Donald Mars, Malcolm Privette, Norman Hommen, Melvin Fregly, James Rogers] Summary: Twenty-one experienced runners were studied before, during and immediately after a marathon race to ascertain whether either depletion of energy substrate or rise in body temperature, or both, contribute to laterace slowing of running pace. Seven runners drank a glucose/electrolyte (GE) solution ad libitum (Na− 21 mmol 1−1, K+ 2.5 mmol l−1, Cl− 17 mmol l − l, PO4 2− 6 mmol 1−1, glucose 28 mmol 1−1) throughout the race; 6 drank water and 8 drank the GE solution diluted 1:1 with water. Although average running speeds for the three groups were not significantly different during the first two-thirds (29 km) of the race, rectal temperature was significantly higher (P < 0.05) and reduction of plasma volume was greater (P <0.05) in runners who replaced sweat losses with water. During the last one-third of the race, the average running pace of the water-replacement group slowed by 37.2%; the pace slowed by 27.9% in the 8 runners who replaced their sweat loss with GE diluted 1:1 with water (1/2 GE) and 18.2% in runners who replaced fluid loss with full-strength solution (GE). Eleven runners (5 in the water group, 4 in the 1/2 GE group and 2 in the GE group) lapsed into a walk/run/walk pace during the last 6 miles of the race. Ten of these had a rectal temperature of 39° C or greater after 29 km of running, and plasma volume in these runners was reduced by more than 10%. Only 1 runner among those who ran steadily throughout the race had such an elevation of temperature and reduction of plasma volume. A significant reduction in plasma glucose concentration (less than 3.3 mmol 1−1) was present in 5 of the 11 walk/run/walk subjects and in none of those who ran steadily. The results are consistent with the suggestion that assumption of the walk/run/walk pace resulted from high body temperature associated with either diminished plasma volume or low blood sugar. Springer-Verlag, 1992 Marathon running nationallicence Body temperature nationallicence Plasma volume nationallicence Blood pressure nationallicence Plasma glucose nationallicence Cade Robert Department of Medicine, The Center for Physical and Motor Fitness, 32610-0204, Gainesville, Florida, USA aut Packer David Department of Medicine, The Center for Physical and Motor Fitness, 32610-0204, Gainesville, Florida, USA aut Zauner Christian Department of Medicine, The Center for Physical and Motor Fitness, 32610-0204, Gainesville, Florida, USA aut Kaufmann David Department of Medicine, The Center for Physical and Motor Fitness, 32610-0204, Gainesville, Florida, USA aut Peterson John Department of Medicine, The Center for Physical and Motor Fitness, 32610-0204, Gainesville, Florida, USA aut Mars Donald Department of Medicine, The Center for Physical and Motor Fitness, 32610-0204, Gainesville, Florida, USA aut Privette Malcolm Department of Medicine, The Center for Physical and Motor Fitness, 32610-0204, Gainesville, Florida, USA aut Hommen Norman Department of Medicine, The Center for Physical and Motor Fitness, 32610-0204, Gainesville, Florida, USA aut Fregly Melvin Department of Medicine, The Center for Physical and Motor Fitness, 32610-0204, Gainesville, Florida, USA aut Rogers James Department of Medicine, The Center for Physical and Motor Fitness, 32610-0204, Gainesville, Florida, USA aut European Journal of Applied Physiology and Occupational Physiology Springer-Verlag 65/6(1992-11-01), 485-491 0301-5548 65:6<485 1992 65 421 https://doi.org/10.1007/BF00602353 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00602353 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Cade Robert Department of Medicine, The Center for Physical and Motor Fitness, 32610-0204, Gainesville, Florida, USA aut NATIONALLICENCE 700 1- Packer David Department of Medicine, The Center for Physical and Motor Fitness, 32610-0204, Gainesville, Florida, USA aut NATIONALLICENCE 700 1- Zauner Christian Department of Medicine, The Center for Physical and Motor Fitness, 32610-0204, Gainesville, Florida, USA aut NATIONALLICENCE 700 1- Kaufmann David Department of Medicine, The Center for Physical and Motor Fitness, 32610-0204, Gainesville, Florida, USA aut NATIONALLICENCE 700 1- Peterson John Department of Medicine, The Center for Physical and Motor Fitness, 32610-0204, Gainesville, Florida, USA aut NATIONALLICENCE 700 1- Mars Donald Department of Medicine, The Center for Physical and Motor Fitness, 32610-0204, Gainesville, Florida, USA aut NATIONALLICENCE 700 1- Privette Malcolm Department of Medicine, The Center for Physical and Motor Fitness, 32610-0204, Gainesville, Florida, USA aut NATIONALLICENCE 700 1- Hommen Norman Department of Medicine, The Center for Physical and Motor Fitness, 32610-0204, Gainesville, Florida, USA aut NATIONALLICENCE 700 1- Fregly Melvin Department of Medicine, The Center for Physical and Motor Fitness, 32610-0204, Gainesville, Florida, USA aut NATIONALLICENCE 700 1- Rogers James Department of Medicine, The Center for Physical and Motor Fitness, 32610-0204, Gainesville, Florida, USA aut NATIONALLICENCE 773 0- European Journal of Applied Physiology and Occupational Physiology Springer-Verlag 65/6(1992-11-01), 485-491 0301-5548 65:6<485 1992 65 421 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer