caa a22 4500 46905459X CHVBK 20180323132839.0 cr unu---uuuuu 170328e19921101xx s 000 0 eng 10.1007/BF00243503 doi (NATIONALLICENCE)springer-10.1007/BF00243503 Branched-chain amino acid supplementation during trekking at high altitude [Elektronische Daten] The effects on loss of body mass, body composition, and muscle power [F. Schena, F. Guerrini, P. Tregnaghi, B. Kayser] Summary: To investigate the influence of a branched-chain amino acid (BCAA) supplementation on chronic hypoxia-related loss of body mass and muscle loss, 16 subjects [age 35.8 (SD 5.6) years] participating in a 21-day trek at a mean altitude of 3,255 (SD 458) m, were divided in two age-, sex- and fitness-matched groups and took either a dietary supplementation of BCAA (5.76, 2.88 and 2.88 g per day of leucine, isoleucine and valine, respectively) or a placebo (PLAC) in a controlled double-blind manner. Daily energy intake at altitude decreased by 4% in both groups compared with sea level. After altitude exposure both groups showed a significant loss of body mass, 1.7% and 2.8% for BCAA and PLAC, respectively. Fat mass had decreased significantly by 11.7% for BCAA and 10.3% for PLAC, whereas BCAA showed a significantly increased lean mass of 1.5%, as opposed to no change in PLAC. Arm muscle cross-sectional area tended to increase in BCAA, whereas there was a significant decrease of 6.8% in PLAC (P<0.05 between groups). The same tendency, although not significant, was observed for the thigh muscle cross-sectional area. On the whole it seemed that PLAC had been catabolizing whereas BCAA had been synthesizing muscle tissue. Single jump height from a squatted position showed a similar tendency to increase in both groups. Lower limb maximal power decreased less in BCAA than in PLAC (2.4% vs 7.8%, P<0.05). We concluded that BCAA supplementation may prevent muscle loss during chronic hypobaric hypoxia. Springer-Verlag, 1992 Branched chain amino acid supplementation nationallicence Altitude nationallicence Trekking nationallicence Loss of mass nationallicence Body composition nationallicence Hypoxia nationallicence Nutrition nationallicence Schena F. Institute of Human Physiology, University of Verona, Strada Le Grazie, I-37134, Verona, Italy aut Guerrini F. Institute of Sports Medicine, Via SS. Trinità 1, I-37121, Verona, Italy aut Tregnaghi P. Institute of Sports Medicine, Via SS. Trinità 1, I-37121, Verona, Italy aut Kayser B. Department of Physiology, CMU, CH-1211, Geneva 4, Switzerland aut European Journal of Applied Physiology and Occupational Physiology Springer-Verlag 65/5(1992-11-01), 394-398 0301-5548 65:5<394 1992 65 421 https://doi.org/10.1007/BF00243503 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00243503 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Schena F. Institute of Human Physiology, University of Verona, Strada Le Grazie, I-37134, Verona, Italy aut NATIONALLICENCE 700 1- Guerrini F. Institute of Sports Medicine, Via SS. Trinità 1, I-37121, Verona, Italy aut NATIONALLICENCE 700 1- Tregnaghi P. Institute of Sports Medicine, Via SS. Trinità 1, I-37121, Verona, Italy aut NATIONALLICENCE 700 1- Kayser B. Department of Physiology, CMU, CH-1211, Geneva 4, Switzerland aut NATIONALLICENCE 773 0- European Journal of Applied Physiology and Occupational Physiology Springer-Verlag 65/5(1992-11-01), 394-398 0301-5548 65:5<394 1992 65 421 Metadata rights reserved Springer special CC-BY-NC licence nationallicence SWISSBIB 214668878 BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer